How nanoparticles can induce dimerization and aggregation of cells in blood or lymph
Artikel i vetenskaplig tidskrift, 2021

By analogy with virions, the binding of biologically-inspired nanoparticles with ligands to the cellular membrane containing receptors depends on the multivalent ligand–receptor interaction, membrane bending, and cytoskeleton deformation. The interplay of these factors results in the existence of the potential minimum and activation barrier on the pathway towards full absorption of a NP. Herein, I hypothesize and show theoretically that the interaction of a NP, bound to one cell, with another cell can stabilize the potential minimum and increase the corresponding activation barrier, i.e., NPs can mediate the formation of long-living pairs of cells and aggregates containing a few cells inside blood and lymphatic vessels.

Cells

Lipid membrane

Model

Nanoparticles

Vessels

Aggregation

Författare

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik, Nano- och biofysik

BioSystems

0303-2647 (ISSN) 18728324 (eISSN)

Vol. 210 104551

Ämneskategorier

Cellbiologi

Cell- och molekylärbiologi

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Styrkeområden

Hälsa och teknik

DOI

10.1016/j.biosystems.2021.104551

PubMed

34597710

Mer information

Senast uppdaterat

2021-10-18