Reconstruction of Genome-Scale Metabolic Model for Hansenula polymorpha Using RAVEN
Kapitel i bok, 2022

Genome-scale metabolic models (GEMs) provide a useful framework for modeling the metabolism of microorganisms. While the applications of GEMs are wide and far reaching, the reconstruction and continuous curation of such models can be perceived as a tedious and time-consuming task. Using RAVEN, a MATLAB-based toolbox designed to facilitate the reconstruction analysis of metabolic networks, this protocol practically demonstrates how researchers can create their own GEMs using a homology-based approach. To provide a complete example, a draft GEM for the industrially relevant yeast Hansenula polymorpha is reconstructed.

Constraint-based model

Metabolism

Genome-scale model

Författare

Francisco Zorrilla

Chalmers, Biologi och bioteknik, Systembiologi

Eduard Kerkhoven

Chalmers, Biologi och bioteknik, Systembiologi

Methods in Molecular Biology

10643745 (ISSN) 1940-6029 (eISSN)

Vol. 2513 271-290

Ämneskategorier

Bioinformatik (beräkningsbiologi)

Inbäddad systemteknik

Datorsystem

DOI

10.1007/978-1-0716-2399-2_16

PubMed

35781211

Mer information

Senast uppdaterat

2024-07-12