Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucan-enriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study
Artikel i vetenskaplig tidskrift, 2022

INTRODUCTION: In 2012, the estimated global prevalence of pre-diabetes was 280 million, and the prevalence is expected to rise to 400 million by 2030. Oat-based foods are a good source of beta-glucans, which have been shown to lower postprandial blood glucose. Studies to evaluate the effectiveness of the long-term intake of beta-glucan-enriched bread as part of a habitual diet among individuals with pre-diabetes are needed. Therefore, we designed a multicentre intervention study in adults with pre-diabetes to investigate the effects of consumption of an oat-derived beta-glucan-enriched bread as part of a normal diet on glycated haemoglobin (HbA1c) in comparison to consumption of whole-grain wheat bread. METHODS AND ANALYSIS: The CarbHealth trial is a multicentre double-blind randomised controlled 16-week dietary intervention trial in participants 40-70 years of age with a body mass index of ≥27 kg/m2 and HbA1c of 35-50 mmol/mol. The study is conducted at four universities located in Norway, Sweden and Germany and uses intervention breads specifically designed for the trial by Nofima AS. The aim is to recruit 250 participants. The primary outcome is the difference in HbA1c between the intervention and the control groups. The main analysis will include intervention group, study centre and baseline HbA1c as independent variables in an analysis of covariance model. ETHICS AND DISSEMINATION: The study protocol was approved by respective ethical authorities in participating countries. The results of the study will be communicated through publication in international scientific journals and presentations at (inter)national conferences. TRIAL REGISTRATION NUMBER: NCT04994327.

PUBLIC HEALTH

Clinical trials

General diabetes

Författare

Thérése Hjorth

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Alena Schadow

Universität Paderborn

Ingrid Revheim

Universitetet i Bergen

Ulrike Spielau

Universitatsklinikum Leipzig und Medizinische Fakultat

Universitetet i Bergen

Lise M. Thomassen

Universitetet i Bergen

Klara Meyer

Universitatsklinikum Leipzig und Medizinische Fakultat

Katja Piotrowski

Universitatsklinikum Leipzig und Medizinische Fakultat

Hanne Rosendahl-Riise

Universitetet i Bergen

Anne Rieder

Norwegian Institute of Food, Fisheries and Aquaculture Research

Paula Varela

Norwegian Institute of Food, Fisheries and Aquaculture Research

Vegard Lysne

Universitetet i Bergen

Helse Bergen Haukeland University Hospital

S. Ballance

Norwegian Institute of Food, Fisheries and Aquaculture Research

Antje Koerner

Universitatsklinikum Leipzig und Medizinische Fakultat

Rikard Landberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Anette Buyken

Universität Paderborn

Jutta Dierkes

Universität Paderborn

BMJ Open

2044-6055 (ISSN) 20446055 (eISSN)

Vol. 12 8 e062066-

Ämneskategorier

Endokrinologi och diabetes

Livsmedelsvetenskap

Näringslära

DOI

10.1136/bmjopen-2022-062066

PubMed

35998955

Mer information

Senast uppdaterat

2023-10-27