Development of thermostable enzyme cocktails
Research Project, 2017
– 2021
The goal of this project is to significantly improve hydrolysis of plant biomass (lignocellulose). Enzymatic hydrolysis is regarded as more sustainable than thermochemical alternatives, but is still expensive and needs improvement. The improvement will here be made by developing and producing heat tolerant enzymes with multiple catalytic domains. Typically, enzymes have one catalytic domain, but in certain organisms ‘multicatalytic’ enzymes are common, and have been shown to outcompete commercial variants. These bacteria we study live in extreme environments such as hot springs, making their enzymes highly stable and active at these temperatures (>70°), and enable higher hydrolysis temperatures than in typical industrial processes. The high temperatures lead to higher hydrolysis rates as well as reduced risks of microbial contamination.
Participants
Johan Larsbrink (contact)
Chalmers, Life Sciences, Industrial Biotechnology
Daniel Krska
Chalmers, Life Sciences, Industrial Biotechnology
Funding
Swedish Energy Agency
Project ID: Dnr 2016‑011207
Funding Chalmers participation during 2018–2019
Formas
Project ID: Dnr 2016-01065
Funding Chalmers participation during 2017–2020
Related Areas of Advance and Infrastructure
Sustainable development
Driving Forces
Energy
Areas of Advance
Life Science Engineering (2010-2018)
Areas of Advance