Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
Journal article, 2009
A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide–alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 MAP kinase, showing IC50 values in the high nanomolar range
Author
Peter Dinér
University of Gothenburg
Terese Andersson
University of Gothenburg
Jimmy Kjellén
University of Gothenburg
Karin Elbing
University of Gothenburg
Stefan Hohmann
University of Gothenburg
Morten Grötli
University of Gothenburg
New J. Chem.,
Vol. 33 1010-1016
Subject Categories
Chemical Sciences
DOI
10.1039/b818909a