Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
Journal article, 2009

A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide–alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 MAP kinase, showing IC50 values in the high nanomolar range

Author

Peter Dinér

University of Gothenburg

Terese Andersson

University of Gothenburg

Jimmy Kjellén

University of Gothenburg

Karin Elbing

University of Gothenburg

Stefan Hohmann

University of Gothenburg

Morten Grötli

University of Gothenburg

New J. Chem.,

Vol. 33 1010-1016

Subject Categories

Chemical Sciences

DOI

10.1039/b818909a

More information

Latest update

4/18/2018