Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
Artikel i vetenskaplig tidskrift, 2009
A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide–alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 MAP kinase, showing IC50 values in the high nanomolar range
Författare
Peter Dinér
Göteborgs universitet
Terese Andersson
Göteborgs universitet
Jimmy Kjellén
Göteborgs universitet
Karin Elbing
Göteborgs universitet
Stefan Hohmann
Göteborgs universitet
Morten Grötli
Göteborgs universitet
New J. Chem.,
Vol. 33 1010-1016
Ämneskategorier
Kemi
DOI
10.1039/b818909a