Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
Artikel i vetenskaplig tidskrift, 2009

A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(I)-catalysed azide–alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38 MAP kinase, showing IC50 values in the high nanomolar range

Författare

Peter Dinér

Göteborgs universitet

Terese Andersson

Göteborgs universitet

Jimmy Kjellén

Göteborgs universitet

Karin Elbing

Göteborgs universitet

Stefan Hohmann

Göteborgs universitet

Morten Grötli

Göteborgs universitet

New J. Chem.,

Vol. 33 1010-1016

Ämneskategorier

Kemi

DOI

10.1039/b818909a