Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.
Journal article, 2017

Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.

Author

Vanessa D de Mello

University of Eastern Finland

Jussi Paananen

University of Eastern Finland

Jaana Lindström

National Institute for Health and Welfare

Maria A Lankinen

University of Eastern Finland

Lin Shi

Swedish University of Agricultural Sciences (SLU)

Johanna Kuusisto

University of Eastern Finland

Jussi Pihlajamäki

Kuopio University Hospital

University of Eastern Finland

Seppo Auriola

University of Eastern Finland

Marko Lehtonen

University of Eastern Finland

Olov Rolandsson

Umeå University

Ingvar A Bergdahl

Umeå University

Elise Nordin

Swedish University of Agricultural Sciences (SLU)

Pirjo Ilanne-Parikka

Tampere University Hospital

Diabetes Centre Finnish Diabetes Association

Sirkka Keinänen-Kiukaanniemi

University of Oulu

Oulu University Hospital

Rikard Landberg

Swedish University of Agricultural Sciences (SLU)

Karolinska Institutet

Johan G Eriksson

Vaasa Central hospital

National Institute for Health and Welfare

University of Helsinki

Helsinki University Central Hospital

Jaakko Tuomilehto

Danube University Krems

National Institute for Health and Welfare

King Abdulaziz University

Kati Hanhineva

University of Eastern Finland

Matti Uusitupa

University of Eastern Finland

Kuopio University Hospital

Scientific Reports

2045-2322 (ISSN)

Vol. 7 46337-

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Nutrition and Dietetics

DOI

10.1038/srep46337

PubMed

28397877

More information

Latest update

6/5/2019 1