Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.
Journal article, 2017

Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.

Author

Vanessa D de Mello

Jussi Paananen

Jaana Lindström

Maria A Lankinen

Lin Shi

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Johanna Kuusisto

Jussi Pihlajamäki

Seppo Auriola

Marko Lehtonen

Olov Rolandsson

Ingvar A Bergdahl

Elise Nordin

Pirjo Ilanne-Parikka

Sirkka Keinänen-Kiukaanniemi

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Johan G Eriksson

Jaakko Tuomilehto

Kati Hanhineva

Matti Uusitupa

Scientific Reports

2045-2322 (ISSN)

Vol. 7 46337-

Areas of Advance

Life Science Engineering

Subject Categories

Nutrition and Dietetics

DOI

10.1038/srep46337

PubMed

28397877

More information

Created

10/7/2017