Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.
Journal article, 2017
Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.
Author
Vanessa D de Mello
University of Eastern Finland
Jussi Paananen
University of Eastern Finland
Jaana Lindström
National Institute for Health and Welfare
Maria A Lankinen
University of Eastern Finland
Lin Shi
Swedish University of Agricultural Sciences (SLU)
Johanna Kuusisto
University of Eastern Finland
Jussi Pihlajamäki
University of Eastern Finland
Kuopio University Hospital
Seppo Auriola
University of Eastern Finland
Marko Lehtonen
University of Eastern Finland
Olov Rolandsson
Umeå University
Ingvar A Bergdahl
Umeå University
Elise Nordin
Swedish University of Agricultural Sciences (SLU)
Pirjo Ilanne-Parikka
Diabetes Centre Finnish Diabetes Association
Tampere University Hospital
Sirkka Keinänen-Kiukaanniemi
Oulu University Hospital
University of Oulu
Rikard Landberg
Swedish University of Agricultural Sciences (SLU)
Karolinska Institutet
Johan G Eriksson
Helsinki University Central Hospital
Vaasa Central hospital
National Institute for Health and Welfare
University of Helsinki
Jaakko Tuomilehto
King Abdulaziz University
National Institute for Health and Welfare
Danube University Krems
Kati Hanhineva
University of Eastern Finland
Matti Uusitupa
University of Eastern Finland
Kuopio University Hospital
Scientific Reports
2045-2322 (ISSN) 20452322 (eISSN)
Vol. 7 46337-Areas of Advance
Life Science Engineering (2010-2018)
Subject Categories
Nutrition and Dietetics
DOI
10.1038/srep46337
PubMed
28397877