Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.
Artikel i vetenskaplig tidskrift, 2017
Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.
Författare
Vanessa D de Mello
Itä-Suomen Yliopisto
Jussi Paananen
Itä-Suomen Yliopisto
Jaana Lindström
National Institute for Health and Welfare
Maria A Lankinen
Itä-Suomen Yliopisto
Lin Shi
Sveriges lantbruksuniversitet (SLU)
Johanna Kuusisto
Itä-Suomen Yliopisto
Jussi Pihlajamäki
Itä-Suomen Yliopisto
Kuopio University Hospital
Seppo Auriola
Itä-Suomen Yliopisto
Marko Lehtonen
Itä-Suomen Yliopisto
Olov Rolandsson
Umeå universitet
Ingvar A Bergdahl
Umeå universitet
Elise Nordin
Sveriges lantbruksuniversitet (SLU)
Pirjo Ilanne-Parikka
Diabetes Centre Finnish Diabetes Association
Tampere University Hospital
Sirkka Keinänen-Kiukaanniemi
Oulu University Hospital
Oulun Yliopisto
Rikard Landberg
Sveriges lantbruksuniversitet (SLU)
Karolinska Institutet
Johan G Eriksson
Helsinki University Central Hospital
Vasa centralsjukhus
National Institute for Health and Welfare
Helsingin Yliopisto
Jaakko Tuomilehto
King Abdulaziz University
National Institute for Health and Welfare
Donau-Universität Krems
Kati Hanhineva
Itä-Suomen Yliopisto
Matti Uusitupa
Itä-Suomen Yliopisto
Kuopio University Hospital
Scientific Reports
2045-2322 (ISSN)
Vol. 7 46337-Styrkeområden
Livsvetenskaper och teknik (2010-2018)
Ämneskategorier
Näringslära
DOI
10.1038/srep46337
PubMed
28397877