Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics
Journal article, 2018
extended Kalman filter
sensitivity equations
first-order conditional estimation (FOCE)
stochastic differential equations
nonlinear mixed effects modeling
Author
Helga Kristín Ólafsdóttir
Chalmers, Mathematical Sciences, Applied Mathematics and Statistics
Fraunhofer-Chalmers Centre
Jacob Leander
Chalmers, Mathematical Sciences, Analysis and Probability Theory
AstraZeneca AB
Fraunhofer-Chalmers Centre
Joachim Almquist
AstraZeneca AB
System Biology
Fraunhofer-Chalmers Centre
Mats Jirstrand
Fraunhofer-Chalmers Centre
AAPS Journal
1550-7416 (eISSN)
Vol. 20 5 88Subject Categories
Computational Mathematics
Probability Theory and Statistics
Control Engineering
DOI
10.1208/s12248-018-0232-7