Mats Jirstrand

Showing 51 publications

2018

Evaluation and translation of combination therapies in oncology – A quantitative approach

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
European Journal of Pharmacology. Vol. 834, p. 327-336
Journal article
2018

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristín Ólafsdóttir, Jacob Leander, Joachim Almquist et al
AAPS Journal. Vol. 20 (5)
Journal article
2018

Modeling of radiation therapy and radiosensitizing agents in tumor xenografts

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
Conference poster
2018

Extending existing structural identifiability analysis methods to mixed-effects models

David Janzén, Mats Jirstrand, Michael Chappell et al
Mathematical Biosciences. Vol. 295, p. 1-10
Journal article
2017

Assessment of cardiotoxic effects from ion channel assay data

Mikael Wallman, Ingemar Jacobson, Mats Jirstrand
Proceedings of Advances in Cell Based Screening 2017
Conference poster
2017

Functional Federated Learning in Erlang

Gregor Ulm, Emil Gustavsson, Mats Jirstrand
Proceedings of the 5th Swedish Workshop on Data Science (SweDS 2017)
Conference poster
2017

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristin Olafsdottir, Jacob Leander, Joachim Almquist et al
Conference poster
2017

Purely Functional Federated Learning in Erlang

Gregor Ulm, Emil Gustavsson, Mats Jirstrand
Proceedings of the 29th Symposium on Implementation and Application of Functional Languages (IFL 2017), p. 160-167
Paper in proceedings
2017

Model-based evaluation of radiation and radiosensitizing agents in oncology

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
CPT: Pharmacometrics and Systems Pharmacology
Journal article
2017

Design Analytics is the Answer, But What Questions Would Product Developers Like to Have Answered?

Ívar Örn Arnarsson, Emil Gustavsson, Johan Malmqvist et al
21st International Conference on Engineering Design, ICED 2017, Vancouver, Canada, 21-25 August 2017. Vol. 7 (DS87-7), p. 71-80
Paper in proceedings
2017

Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments

R. Andersson, T. Kroon, Joachim Almquist et al
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 44 (3), p. 203-222
Journal article
2017

Tumor Static Concentration Curves in Combination Therapy

Tim Cardilin, Joachim E Almqvist, Mats Jirstrand et al
AAPS Journal. Vol. 19 (2), p. 456-467
Journal article
2016

Extending the Tumor Static Concentration curve to average doses - a combination therapy example using radiation therapy

Tim Cardilin, Astrid Zimmermann, Mats Jirstrand et al
Proceedings of the 25th Annual meeting of the Population Approach Group in Europe, PAGE2016
Conference poster
2016

Dose-response-time modelling: Second-generation turnover model with integral feedback control

R. Andersson, Mats Jirstrand, L. Peletier et al
European Journal of Pharmaceutical Sciences. Vol. 81, p. 189-200
Journal article
2016

Towards Big-Data Analysis of Deviation and Error Reports in Product Development Projects

Ívar Örn Arnarsson, Johan Malmqvist, Emil Gustavsson et al
Proceedings of NordDesign 2016, Trondheim, Norway, p. 83-92
Paper in proceedings
2015

Modelling and Analysis of Tumor Growth Inhibition for Combination Therapy using Tumor Static Concentration Curves

Tim Cardilin, Alexandre Sostelly, Johan Gabrielsson et al
Proceedings of the 24th Annual meeting of the Population Approach Group in Europe, PAGE2015
Conference poster
2015

Dose-response-time modelling - Second generation turnover model with integral feedback control

Robert Andersson, Mats Jirstrand, Lambertus A. Peletier et al
Proceedings of the 24th Annual meeting of the Population Approach Group in Europe, PAGE2015
Conference poster
2015

A nonlinear mixed effects approach for modeling the cell-to-cell variability of Mig1 dynamics in yeast.

Joachim Almquist, Loubna Bendrioua, Caroline B. Adiels et al
PLoS ONE. Vol. 10 (4), p. e0124050-
Journal article
2015

Bile canalicular dynamics in hepatocyte sandwich cultures

Raymond Reif, Johan Karlsson, Georgia Günther et al
Archives of Toxicology. Vol. 89 (10), p. 1861-1870
Journal article
2015

Two approaches to study structural identifiability analysis in mixed-effects models

David Janzén, Mats Jirstrand, Michael J. Chappell et al
Proceedings of Pharmacokinetics UK (PKUK) 2015, p. 38-
Conference poster
2015

Sensitivity Equations Provide More Robust Gradients and Faster Computation of the FOCE Approximation to the Population Likelihood

Joachim Almquist, Jacob Leander, Mats Jirstrand
Proceedings of the 24th Annual meeting of the Population Approach Group in Europe, PAGE2015
Conference poster
2015

Structural Identifiability in Mixed-Effects Models: Two different approaches

David Janzén, Mats Jirstrand, Neil D. Evans et al
IFAC-PapersOnLine. Vol. 48 (20), p. 563-568
Paper in proceedings
2015

Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

Joachim Almquist, Jacob Leander, Mats Jirstrand
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 42 (3), p. 191-209
Journal article
2015

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Jacob Leander, Joachim Almquist, Christine Ahlström et al
AAPS Journal. Vol. 17 (3), p. 586-596
Journal article
2014

Joint feedback analysis modeling of nonesterified fatty acids in obese zucker rats and normal sprague-dawley rats after different routes of administration of nicotinic acid

Sofia Tapani, Joachim Almquist, Jacob Leander et al
Journal of Pharmaceutical Sciences. Vol. 103 (8), p. 2571-2584
Journal article
2014

A Mechanistic Lung-Disposition Model for Real-time Simulation of Pharmacokinetics and Pharmacodynamics for Pulmonary Drug Delivery

Elin Boger, Markus Fridén, Ulf Eriksson et al
In proceedings of the 7th Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology
Conference poster
2014

Comparison of approaches for parameter identifiability analysis of biological systems.

Andreas Raue, Johan Karlsson, Maria Pia Saccomani et al
Bioinformatics. Vol. 30 (10), p. 1440-8
Journal article
2014

Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements

Jacob Leander, Torbjörn Lundh, Mats Jirstrand
Mathematical Biosciences. Vol. 251 (1), p. 54-62
Journal article
2014

Input estimation in nonlinear dynamical systems for model – based drug discovery using optimal control techniques

Magnus Trägårdh, Michael Chappell, Niel Evans et al
In proceedings of PKUK 2014
Conference poster
2014

Dose-Response-Time Modelling, Input Estimation and Structural Identiability as tools for Systems Pharmacology

Magnus Trägårdh, David Janzén, Robert Andersson et al
In proceedings of the 7th Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology
Conference poster
2014

Bridging the gaps in systems biology

Marija Cvijovic, Joachim E Almqvist, Jonas Hagmar et al
Molecular Genetics and Genomics. Vol. 289 (5), p. 727-734
Journal article
2014

Mixed-effects modeling using stochastic differential equations - Applications to pharmacokinetic modeling

Jacob Leander, Joachim Almquist, Christine Ahlström et al
Population Approach Group Europe (PAGE) 2014
Conference poster
2014

Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels

Loubna Bendrioua, Maria Smedh, Joachim Almquist et al
Journal of Biological Chemistry. Vol. 289 (18), p. 12863-12875
Journal article
2014

Structural Identifiability Analysis of Large Models of Dynamical Systems

Johan Karlsson, Milena Anguelova, Mats Jirstrand
In proceedings of PKUK 2014
Paper in proceedings
2014

Structural Identifiability in mixed-effects models

David Janzén, James Yates, Mats Jirstrand et al
In proceedings of PKUK 2014
Conference poster
2014

Dose-response-time data analysis of nicotinic acid-induced changes in non-esterified fatty acids in rats

Robert Andersson, Mats Jirstrand, Johan Gabrielsson
In proceedings of PKUK 2014
Conference poster
2014

Kinetic models in industrial biotechnology - Improving cell factory performance

Joachim Almquist, Marija Cvijovic, V. Hatzimanikatis et al
Metabolic Engineering. Vol. 24, p. 38-60
Journal article
2013

A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model.

Annette Krengel, Jan Hauth, Marja-Riitta Taskinen et al
BMC Systems Biology. Vol. 7 (8), p. 33 sidor-
Journal article
2013

Toward Quantifying the Thymic Dysfunctional State in Mouse Models of Inflammatory Bowel Disease

A. Jansson, A. K. Pernestig, P. Nilsson et al
Inflammatory Bowel Diseases. Vol. 19 (4), p. 881-888
Journal article
2012

An Efficient Method for Structural Identiability Analysis of Large Dynamic Systems

Milena Anguelova, Mats Jirstrand, Johan Karlsson
16th IFAC Symposium on System Identification. Vol. 16 (1), p. 941-946
Paper in proceedings
2012

Investigations of a compartmental model for leucine kinetics using non-linear mixed effects models with ordinary and stochastic differential equations.

Martin Berglund, Mikael Sunnåker, Martin Adiels et al
Mathematical medicine and biology : a journal of the IMA. Vol. 29 (4), p. 361-384
Journal article
2012

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

René Meyer, Lorenza A. D'Alessandro, Sandip Kar et al
Frontiers in Physiology. Vol. 3 (451)
Journal article
2012

Minimal output sets for identifiability

Milena Anguelova, Johan Karlsson, Mats Jirstrand
Mathematical Biosciences
Journal article
2012

Optimal posterior density approximation for bearings-only tracking

M. Morelande, Lennart Svensson, J. Hagmar et al
ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, p. 3585-3588
Paper in proceedings
2011

A Method for Zooming of Nonlinear Models of Biochemical Systems

Mikael Sunnåker, Gunnar Cedersund, Mats Jirstrand
BMC Systems Biology. Vol. 5
Journal article
2011

Optimal parameterization of posterior densities using homotopy

Jonas Hagmar, Lennart Svensson, Mark Morelande et al
14th International Conference on Information Fusion, Fusion 2011; Chicago, IL; 5 July 2011 through 8 July 2011
Paper in proceedings
2010

Zooming of states and parameters using a lumping approach including back-translation

Mikael Sunnåker, Henning Schmidt, Mats Jirstrand et al
BMC Systems Biology. Vol. 4 (28)
Journal article
2010

Modeling the Effect of Kv1.5 Block on the Canine Action Potential

Joachim E Almqvist, Mikael Wallman, Ingemar Jacobson et al
Biophysical Journal. Vol. 99 (9), p. 2726-2736
Journal article
2010

A Kinetic Model of the Monocarboxylate Transporter MCT1 and its Interaction with Carbonic Anhydrase II

Joachim E Almqvist, Patrick Lang, Dieter Prätzel-Wolters et al
Journal of Computer Science and Systems Biology. Vol. 3 (5), p. 107-116
Journal article
2010

Biochemical Modeling with Systems Biology Graphical Notation

Mats Jirstrand, Andreas Jansson
Drug Discovery Today. Vol. 15 (9-10), p. 365-370
Journal article

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