Differential Responders to a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota—Data from the MEDGI-Carb Randomized Controlled Trial
Journal article, 2023

The global prevalence of type 2 diabetes mellitus (T2DM) has surged in recent decades, and the identification of differential glycemic responders can aid tailored treatment for the prevention of prediabetes and T2DM. A mixed meal tolerance test (MMTT) based on regular foods offers the potential to uncover differential responders in dynamical postprandial events. We aimed to fit a simple mathematical model on dynamic postprandial glucose data from repeated MMTTs among participants with elevated T2DM risk to identify response clusters and investigate their association with T2DM risk factors and gut microbiota. Data were used from a 12-week multi-center dietary intervention trial involving high-risk T2DM adults, comparing high- versus low-glycemic index foods within a Mediterranean diet context (MEDGICarb). Model-based analysis of MMTTs from 155 participants (81 females and 74 males) revealed two distinct plasma glucose response clusters that were associated with baseline gut microbiota. Cluster A, inversely associated with HbA1c and waist circumference and directly with insulin sensitivity, exhibited a contrasting profile to cluster B. Findings imply that a standardized breakfast MMTT using regular foods could effectively distinguish non-diabetic individuals at varying risk levels for T2DM using a simple mechanistic model.

differential responders

personalized nutrition

clustering

Author

Viktor Skantze

Chalmers, Life Sciences, Food and Nutrition Science

Fraunhofer-Chalmers Centre

Thérése Hjorth

Chalmers, Life Sciences, Food and Nutrition Science

Mikael Wallman

Fraunhofer-Chalmers Centre

Carl Brunius

Chalmers, Life Sciences, Food and Nutrition Science

Johan Dicksved

Swedish University of Agricultural Sciences (SLU)

Erik A. Pelve

Swedish University of Agricultural Sciences (SLU)

A. Esberg

Umeå University

Marilena Vitale

University of Naples Federico II

Rosalba Giacco

Consiglo Nazionale Delle Richerche

University of Naples Federico II

Giuseppina Costabile

University of Naples Federico II

Robert E. Bergia

College of Health and Human Sciences

Mats Jirstrand

Fraunhofer-Chalmers Centre

Wayne W. Campbell

College of Health and Human Sciences

Gabriele Riccardi

University of Naples Federico II

Rikard Landberg

Chalmers, Life Sciences, Food and Nutrition Science

Nutrients

2072-6643 (ISSN) 20726643 (eISSN)

Vol. 15 20 4369

Precision Prevention of Cardiometabolic Diseases Through Personalized Nutrition Guided by Metabolite Biomarker Signatures

Swedish Research Council (VR) (2022-00924), 2023-01-01 -- 2025-12-31.

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Subject Categories

Endocrinology and Diabetes

Nutrition and Dietetics

DOI

10.3390/nu15204369

More information

Latest update

11/17/2023