Second-generation TNFα turnover model for improved analysis of test compound interventions in LPS challenge studies
Journal article, 2021
Lipopolysaccharides
Non-linear mixed effects
Sprague-Dawley rats
Turnover models
LPS challenge studies
Tumor necrosis factor alpha
Author
Julia Larsson
Chalmers, Mathematical Sciences, Applied Mathematics and Statistics
Fraunhofer-Chalmers Centre
Edmund Hoppe
Grünenthal GmbH
Michael Gautrois
Grünenthal GmbH
Marija Cvijovic
Chalmers, Mathematical Sciences, Applied Mathematics and Statistics
University of Gothenburg
Mats Jirstrand
Fraunhofer-Chalmers Centre
European Journal of Pharmaceutical Sciences
0928-0987 (ISSN) 1879-0720 (eISSN)
Vol. 165 105937Subject Categories
Pharmaceutical Sciences
Bioinformatics (Computational Biology)
Probability Theory and Statistics
DOI
10.1016/j.ejps.2021.105937
PubMed
34260892