Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Journal article, 2014

Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Nuclear Translocation

Yeast Physiology

Glucose Metabolism

AMP-activated Kinase (AMPK)

Dynamic Control

Signal Transduction


Loubna Bendrioua

University of Gothenburg

Maria Smedh

University of Gothenburg

Joachim Almquist

Chalmers, Chemical and Biological Engineering, Life Sciences

Marija Cvijovic

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematics

Mats Jirstrand

Fraunhofer-Chalmers Centre

Mattias Goksör

University of Gothenburg

Caroline B. Adiels

University of Gothenburg

Stefan Hohmann

University of Gothenburg

Journal of Biological Chemistry

0021-9258 (ISSN) 1083-351X (eISSN)

Vol. 289 18 12863-12875

Subject Categories

Biochemistry and Molecular Biology



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