Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Artikel i vetenskaplig tidskrift, 2014

Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Yeast Physiology

Dynamic Control

Nuclear Translocation

AMP-activated Kinase (AMPK)

Signal Transduction

Glucose Metabolism

Författare

Loubna Bendrioua

Göteborgs universitet

Maria Smedh

Göteborgs universitet

Joachim Almquist

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Marija Cvijovic

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Matematik

Mats Jirstrand

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Mattias Goksör

Göteborgs universitet

Caroline B. Adiels

Göteborgs universitet

Stefan Hohmann

Göteborgs universitet

Journal of Biological Chemistry

0021-9258 (ISSN) 1083-351X (eISSN)

Vol. 289 12863-12875

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1074/jbc.M114.547976