Joachim Almquist

Showing 28 publications

2022

Exposure-response modeling improves selection of radiation and radiosensitizer combinations

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 49 (2), p. 167-178
Journal article
2020

NLMEModeling: A Wolfram Mathematica Package for Nonlinear Mixed Effects Modeling of Dynamical Systems

Jacob Leander, Joachim Almquist, Anna Johnning et al
Preprint
2019

Modeling long-term tumor growth and kill after combinations of radiation and radiosensitizing agents

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
Cancer Chemotherapy and Pharmacology. Vol. 83 (6), p. 1159-1173
Journal article
2019

Parameter Estimation for Nonlinear Mixed Effects Models Implemented in Mathematica

Jacob Leander, Joachim Almquist, Helga Kristín Ólafsdóttir et al
Conference poster
2018

Modeling of radiation therapy and radiosensitizing agents in tumor xenografts

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
Conference poster
2018

Model-based evaluation of radiation and radiosensitizing agents in oncology

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
CPT: Pharmacometrics and Systems Pharmacology. Vol. 7 (1), p. 51-58
Journal article
2018

Overexpressing cell systems are a competitive option to primary adipocytes when predicting in vivo potency of dual GPR81/GPR109A agonists

Joachim Almquist, Daniel Hovdal, Christine Ahlström et al
European Journal of Pharmaceutical Sciences. Vol. 114, p. 155-165
Journal article
2018

Evaluation and translation of combination therapies in oncology – A quantitative approach

Tim Cardilin, Joachim Almquist, Mats Jirstrand et al
European Journal of Pharmacology. Vol. 834, p. 327-336
Journal article
2018

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristín Ólafsdóttir, Jacob Leander, Joachim Almquist et al
AAPS Journal. Vol. 20 (5)
Journal article
2017

Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin

S. Pehrsson, K. J. Johansson, A. Janefeldt et al
Journal of Thrombosis and Haemostasis. Vol. 15 (6), p. 1213-1222
Journal article
2017

Multiple computational modeling approaches for prediction of wound healing dynamics following pharmacologic intervention

S. M. Rikard, Joachim Almquist, A. Lundahl et al
Biomedical Engineering Society (BMES) annual meeting, Phoenix, AZ, USA, 11-14 October 2017
Paper in proceeding
2017

Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments

R. Andersson, T. Kroon, Joachim Almquist et al
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 44 (3), p. 203-222
Journal article
2017

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristin Olafsdottir, Jacob Leander, Joachim Almquist et al
Conference poster
2017

Tumor Static Concentration Curves in Combination Therapy

Tim Cardilin, Joachim E Almqvist, Mats Jirstrand et al
AAPS Journal. Vol. 19 (2), p. 456-467
Journal article
2016

Extending the Tumor Static Concentration curve to average doses - a combination therapy example using radiation therapy

Tim Cardilin, Astrid Zimmermann, Mats Jirstrand et al
Proceedings of the 25th Annual meeting of the Population Approach Group in Europe, PAGE2016
Conference poster
2016

Unraveling the Pharmacokinetic Interaction of Ticagrelor and MEDI2452 (Ticagrelor Antidote) by Mathematical Modeling

Joachim Almquist, M. Penney, S. Pehrsson et al
CPT: Pharmacometrics and Systems Pharmacology. Vol. 5 (6), p. 313-323
Journal article
2015

Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

Joachim Almquist, Jacob Leander, Mats Jirstrand
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 42 (3), p. 191-209
Journal article
2015

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Jacob Leander, Joachim Almquist, Christine Ahlström et al
AAPS Journal. Vol. 17 (3), p. 586-596
Journal article
2015

A nonlinear mixed effects approach for modeling the cell-to-cell variability of Mig1 dynamics in yeast.

Joachim Almquist, Loubna Bendrioua, Caroline B. Adiels et al
PLoS ONE. Vol. 10 (4), p. e0124050-
Journal article
2014

Joint feedback analysis modeling of nonesterified fatty acids in obese zucker rats and normal sprague-dawley rats after different routes of administration of nicotinic acid

Sofia Tapani, Joachim Almquist, Jacob Leander et al
Journal of Pharmaceutical Sciences. Vol. 103 (8), p. 2571-2584
Journal article
2014

Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels

Loubna Bendrioua, Maria Smedh, Joachim Almquist et al
Journal of Biological Chemistry. Vol. 289 (18), p. 12863-12875
Journal article
2014

Bridging the gaps in systems biology

Marija Cvijovic, Joachim Almquist, Jonas Hagmar et al
Molecular Genetics and Genomics. Vol. 289 (5), p. 727-734
Review article
2014

Mixed-effects modeling using stochastic differential equations - Applications to pharmacokinetic modeling

Jacob Leander, Joachim Almquist, Christine Ahlström et al
Population Approach Group Europe (PAGE) 2014
Conference poster
2014

Kinetic models in industrial biotechnology - Improving cell factory performance

Joachim Almquist, Marija Cvijovic, V. Hatzimanikatis et al
Metabolic Engineering. Vol. 24, p. 38-60
Review article
2010

A Kinetic Model of the Monocarboxylate Transporter MCT1 and its Interaction with Carbonic Anhydrase II

Joachim E Almqvist, Patrick Lang, Dieter Prätzel-Wolters et al
Journal of Computer Science and Systems Biology. Vol. 3 (5), p. 107-116
Journal article
2010

Modeling the Effect of Kv1.5 Block on the Canine Action Potential

Joachim E Almqvist, Mikael Wallman, Ingemar Jacobson et al
Biophysical Journal. Vol. 99 (9), p. 2726-2736
Journal article

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