Jacob Leander

Publications (14)
Projects (0)

Showing 14 publications

2022

A stochastic mixed effects model to assess treatment effects and fluctuations in home-measured peak expiratory flow and the association with exacerbation risk in asthma

Jacob Leander, Mats Jirstrand, Ulf Eriksson et al

CPT: Pharmacometrics and Systems Pharmacology. Vol. 11 (2), p. 212-224

Journal article

Show project

2021

Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

Jacob Leander

Doctoral thesis

2021

Nonlinear Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems in Wolfram Mathematica

Jacob Leander, Joachim Almquist, Anna Johnning et al

IFAC-PapersOnLine. Vol. 54 (7), p. 409-414

Paper in proceeding

2020

NLMEModeling: A Wolfram Mathematica Package for Nonlinear Mixed Effects Modeling of Dynamical Systems

Jacob Leander, Joachim Almquist, Anna Johnning et al

Preprint

2019

Parameter Estimation for Nonlinear Mixed Effects Models Implemented in Mathematica

Jacob Leander, Joachim Almquist, Helga Kristín Ólafsdóttir et al

Conference poster

2018

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristín Ólafsdóttir, Jacob Leander, Joachim Almquist et al

AAPS Journal. Vol. 20 (5)

Journal article

2017

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics

Helga Kristin Olafsdottir, Jacob Leander, Joachim Almquist et al

Conference poster

2015

Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

Joachim Almquist, Jacob Leander, Mats Jirstrand

Journal of Pharmacokinetics and Pharmacodynamics. Vol. 42 (3), p. 191-209

Journal article

2015

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Jacob Leander, Joachim Almquist, Christine Ahlström et al

AAPS Journal. Vol. 17 (3), p. 586-596

Journal article

2015

Sensitivity Equations Provide More Robust Gradients and Faster Computation of the FOCE Approximation to the Population Likelihood

Joachim Almquist, Jacob Leander, Mats Jirstrand

Conference poster

2014

Joint feedback analysis modeling of nonesterified fatty acids in obese zucker rats and normal sprague-dawley rats after different routes of administration of nicotinic acid

Sofia Tapani, Joachim Almquist, Jacob Leander et al

Journal of Pharmaceutical Sciences. Vol. 103 (8), p. 2571-2584

Journal article

2014

Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements

Jacob Leander, Torbjörn Lundh, Mats Jirstrand

Mathematical Biosciences. Vol. 251 (1), p. 54-62

Journal article

2014

Mixed-effects modeling using stochastic differential equations - Applications to pharmacokinetic modeling

Jacob Leander, Joachim Almquist, Christine Ahlström et al

Population Approach Group Europe (PAGE) 2014

Conference poster

2014

Contributions to nonlinear mixed-effects modeling

Jacob Leander

Licentiate thesis

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