Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
Journal article, 2018

Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.

Author

Enrique Almanza-Aguilera

University of Barcelona

Instituto de Salud Carlos III

Carl Brunius

Swedish University of Agricultural Sciences (SLU)

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

M. Rosa Bernal-Lopez

Instituto de Salud Carlos III

Hospital Regional Universitario Carlos Haya

Mar Garcia-Aloy

University of Barcelona

Instituto de Salud Carlos III

Francisco Madrid-Gambin

University of Barcelona

Instituto de Salud Carlos III

Francisco J. Tinahones

Hospital Universitari Virgen de la Victoria

Instituto de Salud Carlos III

Ricardo Gómez-Huelgas

Hospital Regional Universitario Carlos Haya

Instituto de Salud Carlos III

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Swedish University of Agricultural Sciences (SLU)

Cristina Andres-Lacueva

University of Barcelona

Instituto de Salud Carlos III

Journal of Proteome Research

1535-3893 (ISSN) 1535-3907 (eISSN)

Vol. 17 8 2600-2610

Subject Categories

Physiotherapy

Other Clinical Medicine

Nutrition and Dietetics

DOI

10.1021/acs.jproteome.8b00042