Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women
Artikel i vetenskaplig tidskrift, 2018

Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.

Författare

Enrique Almanza-Aguilera

Universitat de Barcelona

Instituto de Salud Carlos III

Carl Brunius

Sveriges lantbruksuniversitet (SLU)

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

M. Rosa Bernal-Lopez

Instituto de Salud Carlos III

Hospital Regional Universitario Carlos Haya

Mar Garcia-Aloy

Universitat de Barcelona

Instituto de Salud Carlos III

Francisco Madrid-Gambin

Universitat de Barcelona

Instituto de Salud Carlos III

Francisco J. Tinahones

Hospital Universitari Virgen de la Victoria

Instituto de Salud Carlos III

Ricardo Gómez-Huelgas

Hospital Regional Universitario Carlos Haya

Instituto de Salud Carlos III

Rikard Landberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Sveriges lantbruksuniversitet (SLU)

Cristina Andres-Lacueva

Universitat de Barcelona

Instituto de Salud Carlos III

Journal of Proteome Research

1535-3893 (ISSN) 1535-3907 (eISSN)

Vol. 17 8 2600-2610

Ämneskategorier

Sjukgymnastik

Annan klinisk medicin

Näringslära

DOI

10.1021/acs.jproteome.8b00042

Mer information

Senast uppdaterat

2018-08-21