A nanofluidic device for parallel single nanoparticle catalysis in solution
Journal article, 2019

Studying single catalyst nanoparticles, during reaction, eliminates averaging effects that are an inherent limitation of ensemble experiments. It enables establishing structure-function correlations beyond averaged properties by including particle-specific descriptors such as defects, chemical heterogeneity and microstructure. Driven by these prospects, several single particle catalysis concepts have been implemented. However, they all have limitations such as low throughput, or that they require very low reactant concentrations and/or reaction rates. In response, we present a nanofluidic device for highly parallelized single nanoparticle catalysis in solution, based on fluorescence microscopy. Our device enables parallel scrutiny of tens of single nanoparticles, each isolated inside its own nanofluidic channel, and at tunable reaction conditions, ranging from the fully mass transport limited regime to the surface reaction limited regime. In a wider perspective, our concept provides a versatile platform for highly parallelized single particle catalysis in solution and constitutes a promising application area for nanofluidics.

Author

Sune Levin

Chalmers, Biology and Biological Engineering, Chemical Biology

Joachim Fritzsche

Chalmers, Physics, Chemical Physics

Sara Nilsson

Chalmers, Physics, Chemical Physics

August Runemark

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Bhausaheb Kashinath Dhokale

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Henrik Ström

Chalmers, Mechanics and Maritime Sciences, Fluid Dynamics

Henrik Sundén

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Christoph Langhammer

Chalmers, Physics, Chemical Physics

Fredrik Westerlund

Chalmers, Biology and Biological Engineering, Chemical Biology

Nature Communications

2041-1723 (ISSN)

Vol. 10 1 4426-

Subject Categories

Polymer Chemistry

Other Chemical Engineering

Other Chemistry Topics

DOI

10.1038/s41467-019-12458-1

PubMed

31562383

More information

Latest update

11/11/2019