Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: A randomized crossover trial
Journal article, 2020

A whole-grain (WG)-rich diet has shown to have potential for both prevention and treatment of the metabolic syndrome (MetS), which is a cluster of risk factors that increase the risk of type 2 diabetes and cardiovascular disease. Different WGs may have different health effects. WG rye, in particular, may improve glucose homeostasis and blood lipids, possibly mediated through fermentable dietary fiber and lignans. Recent studies have also suggested a crucial role of the gut microbiota in response to WG. Objectives: The aim was to investigate WG rye, alone and with lignan supplements [secoisolariciresinol diglucoside (SDG)], and WG wheat diets on glucose tolerance [oral-glucose-tolerance test (OGTT)], other cardiometabolic outcomes, enterolignans, and microbiota composition. Moreover, we exploratively evaluated the role of gut microbiota enterotypes in response to intervention diets. Methods: Forty men with MetS risk profile were randomly assigned to WG diets in an 8-wk crossover study. The rye diet was supplemented with 280 mg SDG at weeks 4-8. Effects of treatment were evaluated by mixed-effects modeling, and effects on microbiota composition and the role of gut microbiota as a predictor of response to treatment were analyzed by random forest plots. Results: The WG rye diet (± SDG supplements) did not affect the OGTT compared with WG wheat. Total and LDL cholesterol were lowered (-0.06 and -0.09 mmol/L, respectively; P < 0.05) after WG rye compared with WG wheat after 4 wk but not after 8 wk. WG rye resulted in higher abundance of Bifidobacterium [fold-change (FC) = 2.58, P < 0.001] compared with baseline and lower abundance of Clostridium genus compared with WG wheat (FC = 0.54, P = 0.02). The explorative analyses suggest that baseline enterotype is associated with total and LDL-cholesterol response to diet. Conclusions: WG rye, alone or with SDG supplementation, compared with WG wheat did not affect glucose metabolism but caused transient LDL-cholesterol reduction. The effect of WG diets appeared to differ according to enterotype. This trial was registered at www.clinicaltrials.gov as NCT02987595.

lipid profile

wheat

lignan

enterotype

glucose-tolerance test

whole grain

cardiometabolic

rye

Author

Anne Kirstine Eriksen

Danish Cancer Research Society Center

Swedish University of Agricultural Sciences (SLU)

Carl Brunius

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Mohsen Mazidi

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Per M. Hellström

Uppsala University

Ulf Risérus

Uppsala University

Kia Noehr Iversen

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Rikard Fristedt

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Li Sun

Swedish University of Agricultural Sciences (SLU)

Yi Huang

Swedish University of Agricultural Sciences (SLU)

Guangxi University

N. Nørskov

Aarhus University

Knud Erik B. Knudsen

Aarhus University

C. Kyro

Danish Cancer Research Society Center

A. Olsen

Danish Cancer Research Society Center

Anne Tjønneland

Danish Cancer Research Society Center

Johan Dicksved

Swedish University of Agricultural Sciences (SLU)

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

American Journal of Clinical Nutrition

0002-9165 (ISSN)

Vol. 111 4 864-876

Subject Categories

Endocrinology and Diabetes

Other Clinical Medicine

Nutrition and Dietetics

DOI

10.1093/ajcn/nqaa026

PubMed

32097450

More information

Latest update

8/24/2020