Monitoring the Porosity of Pharmaceutical Tablets Using THz Frequency Domain Spectroscopy
Other conference contribution, 2021

In this paper, terahertz frequency domain spectroscopy (THz-FDS) in transmission mode has been employed to study the impact of design parameters of tablets such as initial particle size, drug concentration and compaction force, on their porosity. The complex transmission coefficient S21 of 69 tablets were measured using a vector network analyzer in the frequency range of 500-750 GHz. The results show that excipient particle size and compaction force have significant effects on the pore structure of the tablets and THz-FDS reveals to be a very promising tool in monitoring the porosity of pharmaceutical tablets.

Author

Anis Moradikouchi

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

Anders Sparén

AstraZeneca R&D

Staffan Folestad

AstraZeneca R&D

Jan Stake

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

Helena Rodilla

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

9th International THz-Bio Workshop
, Italy,

Areas of Advance

Information and Communication Technology

Materials Science

Infrastructure

Kollberg Laboratory

Subject Categories

Electrical Engineering, Electronic Engineering, Information Engineering

More information

Latest update

5/12/2021