Monitoring the Porosity of Pharmaceutical Tablets Using THz Frequency Domain Spectroscopy
Övrigt konferensbidrag, 2021

In this paper, terahertz frequency domain spectroscopy (THz-FDS) in transmission mode has been employed to study the impact of design parameters of tablets such as initial particle size, drug concentration and compaction force, on their porosity. The complex transmission coefficient S21 of 69 tablets were measured using a vector network analyzer in the frequency range of 500-750 GHz. The results show that excipient particle size and compaction force have significant effects on the pore structure of the tablets and THz-FDS reveals to be a very promising tool in monitoring the porosity of pharmaceutical tablets.

Författare

Anis Moradikouchi

Chalmers, Mikroteknologi och nanovetenskap (MC2), Terahertz- och millimetervågsteknik

Anders Sparén

AstraZeneca R&D

Staffan Folestad

AstraZeneca R&D

Jan Stake

Chalmers, Mikroteknologi och nanovetenskap (MC2), Terahertz- och millimetervågsteknik

Helena Rodilla

Chalmers, Mikroteknologi och nanovetenskap (MC2), Terahertz- och millimetervågsteknik

9th International THz-Bio Workshop
, Italy,

Styrkeområden

Informations- och kommunikationsteknik

Materialvetenskap

Infrastruktur

Kollberglaboratoriet

Ämneskategorier

Elektroteknik och elektronik

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Senast uppdaterat

2021-05-12