Small Variation of Active Pharmaceutical Ingredient Concentration Can Be Observed with THz Frequency Domain Spectroscopy
Paper in proceeding, 2021
Terahertz frequency-domain spectroscopy (THz-FDS) has been employed to study the result of the variation of active pharmaceutical ingredients (API) on the effective refractive index of pharmaceutical tablets. A quasi-optical set-up with four off-axis parabolic mirrors was used to measure the effective refractive index of tablets in the frequency range of 500-750 GHz. It was observed that a small variation in API concentration can be detected using accurate measurements of the complex transmission coefficients. As a result, THz-FDS reveals to be an effective technique in monitoring the physical properties of pharmaceutical tablets
Author
Anis Moradikouchi
Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory
AstraZeneca R&D
Anders Sparén
AstraZeneca R&D
Staffan Folestad
AstraZeneca R&D
Jan Stake
Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory
Helena Rodilla
Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory
International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
21622027 (ISSN) 21622035 (eISSN)
Vol. 2021-August9781728194240 (ISBN)
International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Chengdu, China,
Chengdu, China,
THz sensors aiding smart production of precision medicines
Swedish Foundation for Strategic Research (SSF) (ID17-0011), 2017-12-01 -- 2023-12-31.
Areas of Advance
Information and Communication Technology
Materials Science
Infrastructure
Kollberg Laboratory
Subject Categories
Other Electrical Engineering, Electronic Engineering, Information Engineering
DOI
10.1109/IRMMW-THz50926.2021.9567162