Small Variation of Active Pharmaceutical Ingredient Concentration Can Be Observed with THz Frequency Domain Spectroscopy
Paper i proceeding, 2021
Terahertz frequency-domain spectroscopy (THz-FDS) has been employed to study the result of the variation of active pharmaceutical ingredients (API) on the effective refractive index of pharmaceutical tablets. A quasi-optical set-up with four off-axis parabolic mirrors was used to measure the effective refractive index of tablets in the frequency range of 500-750 GHz. It was observed that a small variation in API concentration can be detected using accurate measurements of the complex transmission coefficients. As a result, THz-FDS reveals to be an effective technique in monitoring the physical properties of pharmaceutical tablets
Författare
Anis Moradikouchi
Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik
AstraZeneca R&D
Anders Sparén
AstraZeneca R&D
Staffan Folestad
AstraZeneca R&D
Jan Stake
Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik
Helena Rodilla
Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik
International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
21622027 (ISSN) 21622035 (eISSN)
Vol. 2021-August9781728194240 (ISBN)
International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Chengdu, China,
Chengdu, China,
Terahertsteknik för tillverkning av moderna läkemedel
Stiftelsen för Strategisk forskning (SSF) (ID17-0011), 2017-12-01 -- 2023-12-31.
Styrkeområden
Informations- och kommunikationsteknik
Materialvetenskap
Infrastruktur
Kollberglaboratoriet
Ämneskategorier
Annan elektroteknik och elektronik
DOI
10.1109/IRMMW-THz50926.2021.9567162