Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion
Journal article, 2022
mRNA delivery
protein corona
ionizable lipid nanoparticle
lipoprotein
endosomal membrane
Author
Nima Aliakbarinodehi
Chalmers, Physics, Nano and Biophysics
Audrey Gallud
Chalmers, Biology and Biological Engineering, Chemical Biology
AstraZeneca AB
Mokhtar Mapar
Chalmers, Physics, Nano and Biophysics
Emelie Vilhelmsson Wesén
Chalmers, Biology and Biological Engineering, Chemical Biology
Sahar Heydari
Chalmers, Biology and Biological Engineering, Chemical Biology
Yujia Jing
AstraZeneca AB
Gustav Emilsson
AstraZeneca AB
Kai Liu
AstraZeneca AB
Alan Sabirsh
AstraZeneca AB
Vladimir Zhdanov
Russian Academy of Sciences
Chalmers, Physics
Lennart Lindfors
AstraZeneca AB
Elin Esbjörner Winters
Chalmers, Biology and Biological Engineering, Chemical Biology
Fredrik Höök
Chalmers, Physics, Nano and Biophysics
ACS Nano
1936-0851 (ISSN) 1936-086X (eISSN)
Vol. 16 12 20163-20173Subject Categories
Physical Chemistry
Biochemistry and Molecular Biology
Biophysics
DOI
10.1021/acsnano.2c04829
PubMed
36511601