Elin Esbjörner Winters

Associate Professor at Chemical Biology

Elin Esbjörner is Associate Professor of Chemical Biology. Her research group studies protein misfolding and amyloid formation phenomena related to neurodegenerative diseases, using a combination of in vitro biophysics methods and cell biological approaches, including fluorescence microscopies and live cell imaging. The group focuses on how amyloid proteins interact with cells and cellular membranes, on their cell uptake and trafficking mechanisms, as well as on how different biological and pharmacological modulators affect the amyloid formation process. Elin is also a Principle Investigation in the for functional RNA delivery, where her group collaborates extensively with chemists and physicists to explore fundamental mechanisms for effective cellular uptake (endocytosis) and cytosolic delivery of nucleic-acid based drugs. Within this consortium, Elin’s group also contributes to the development of new fluorescent probes and bioanalytical methods to explore the interaction of drug delivery vectors with cells.

Source: chalmers.se

Contact Details ORCID

Publications (60)
Projects (14)

Showing 60 publications

2024

The inhibition of fibril formation of lysozyme by sucrose and trehalose

Kajsa Ahlgren, Fritjof Havemeister, Julia Andersson et al

RSC Advances. Vol. 14 (17), p. 11921-11931

Journal article

Show project

2024

CATIONIC NANOPARTICLES MODULATE ELECTROSTATIC INTERACTIONS IN CATABOLIC CARTILAGE

Ula von Mentzer, Fritjof Havemeister, Loise Råberg et al

Osteoarthritis and Cartilage. Vol. 32, p. S304-S304

Other conference contribution

2024

Extracellular Vesicles Slow Down Aβ(1-42) Aggregation by Interfering with the Amyloid Fibril Elongation Step

Vesa Halipi, Nima Sasanian, Julia Feng et al

ACS Chemical Neuroscience. Vol. 15 (5), p. 944-954

Journal article

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2024

Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleoside phosphate analogues

Pauline Pfeiffer, Jesper Nilsson, Audrey Gallud et al

Nucleic Acids Research. Vol. 52 (17), p. 10102-10118

Journal article

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2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Sriram Kesarimangalam, Marziyeh Ghaeidamini et al

European Biophysics Journal. Vol. 52 (SUPPL 1), p. S205-S205

Other conference contribution

2023

Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells

Shadi Rahimi, Daniel van Leeuwen, Fariba Roshanzamir et al

Pharmaceutics. Vol. 15 (2)

Journal article

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2023

Supported Lipid Bilayer Platform for Characterization of Lipid Nanoparticle-Based Endosomal Escape Mechanism

Simon Niederkofler, Petteri Parkkila, Elin Esbjörner Winters et al

European Biophysics Journal. Vol. 52 (SUPPL 1), p. S198-S198

Other text in scientific journal

2023

Pore formation by melittin in porous silica-supported lipid membranes

Nicola Garlet, Björn Agnarsson, Simon Niederkofler et al

European Biophysics Journal. Vol. 52 (Suppl 1), p. S131-S131

Other text in scientific journal

2023

Monovalent cations have different effects on the assembly kinetics and morphology of α-synuclein amyloid fibrils

Fritjof Havemeister, Marziyeh Ghaeidamini, Elin Esbjörner Winters

Biochemical and Biophysical Research Communications. Vol. 679, p. 31-36

Journal article

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2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian, Rajhans Sharma, Quentin Lubart et al

Nanoscale. Vol. 15 (46), p. 18737-18744

Journal article

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2022

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

Jeremy P. Bost, Miina Ojansivu, Michael J. Munson et al

Communications Biology. Vol. 5 (1)

Journal article

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2022

Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion

Nima Aliakbarinodehi, Audrey Gallud, Mokhtar Mapar et al

ACS Nano. Vol. 16 (12), p. 20163-20173

Journal article

2022

Label-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles

Barbora Spackova, Henrik Klein Moberg, Joachim Fritzsche et al

Nature Methods. Vol. 19 (6), p. 751-758

Journal article

2022

Single-shot self-supervised object detection in microscopy

Benjamin Midtvedt, Jesús Pineda, Fredrik Skärberg et al

Nature Communications. Vol. 13 (1)

Journal article

2021

A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

Michael J. Munson, Gwen O’Driscoll, Andreia M. Silva et al

Communications Biology. Vol. 4 (1)

Journal article

2021

Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery

Tom Baladi, Jesper Nilsson, Audrey Gallud et al

Journal of the American Chemical Society. Vol. 143 (14), p. 5413-5424

Journal article

2021

Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics

Jesper Nilsson, Tom Baladi, Audrey Gallud et al

Scientific Reports. Vol. 11 (1)

Journal article

2021

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

Jeremy P. Bost, Hanna Barriga, Margaret N. Holme et al

ACS Nano. Vol. 15 (9), p. 13993-14021

Review article

2020

Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer's Disease Peptide Aβ(1-42)

Emelie Vilhelmsson Wesén, Richard Lundmark, Elin Esbjörner Winters

ACS Chemical Neuroscience. Vol. 11 (13), p. 1925-1936

Journal article

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2020

Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

Quentin Lubart, Jonas Hannestad, Hudson Pace et al

Physical Chemistry Chemical Physics. Vol. 22 (16), p. 8781-8790

Journal article

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2020

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

Quentin Lubart, Sune Levin, Stephan Block et al

Other conference contribution

2020

The Liver and Kidneys mediate clearance of cardiac troponin in the rat

Aida Muslimovic, Vincent Fridén, Olav Tenstad et al

Scientific Reports. Vol. 10 (1)

Journal article

2020

Novel clearance of muscle proteins by muscle cells

Aida Muslimovic, Vincent Fridén, Karin Starnberg et al

European Journal of Cell Biology. Vol. 99 (8)

Journal article

2020

Independent Size and Fluorescence Emission Determination of Individual Biological Nanoparticles Reveals that Lipophilic Dye Incorporation Does Not Scale with Particle Size

Silver Jõemetsa, Paul Joyce, Quentin Lubart et al

Langmuir. Vol. 36 (33), p. 9693-9700

Journal article

2020

Amyloid formation of bovine insulin is retarded in moderately acidic pH and by addition of short-chain alcohols

David Bernson, Almedina Basic, MD Tuhin Abed et al

European Biophysics Journal. Vol. 49 (2), p. 145-153

Journal article

2020

Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity

Xiaolu Zhang, Emelie Vilhelmsson Wesén, Ranjeet Kumar et al

ACS Chemical Neuroscience. Vol. 11 (3), p. 233-241

Journal article

2020

Graphene oxide sheets and quantum dots inhibit alpha-synuclein amyloid formation by different mechanisms

Marziyeh Ghaeidamini, David Bernson, Nima Sasanian et al

Nanoscale. Vol. 12 (37), p. 19450-19460

Journal article

Show project

2020

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro

Nima Sasanian, David Bernson, Istvan Horvath et al

Biomolecules. Vol. 10 (6), p. 1-19

Journal article

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2020

Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers

Tony Werner, David Bernson, Elin Esbjörner Winters et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (45), p. 27997-28004

Journal article

2019

High throughput size-determination and multiplexed fluorescence analysis of single biological particles in a nanofluidic device

Quentin Lubart, Sune Levin, Stephan Block et al

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, p. 1420-1421

Paper in proceeding

2019

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye to Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Janice S.W. Ng, Maya A. Hanspal, Naunehal S. Matharu et al

Biochemistry. Vol. 58 (39), p. 4086-4095

Journal article

2018

Cell surface proteoglycan-mediated uptake and accumulation of the Alzheimer's disease peptide Aβ(1–42)

Emelie Vilhelmsson Wesén, Audrey Gallud, Alexandra Paul et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1860 (11), p. 2204-2214

Journal article

2018

Copper Chaperone Atox1 Interacts with Cell Cycle Proteins

Maria Matson Dzebo, Stephanie Blockhuys, Sebastian Valenzuela et al

Computational and Structural Biotechnology Journal. Vol. 16, p. 443-449

Journal article

2017

Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40)

Emelie Vilhelmsson Wesén, Gavin Jeffries, Maria Matson Dzebo et al

Scientific Reports. Vol. 7 (1)

Journal article

2017

Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction

David Lindberg, Anna Wenger, Elin Sundin et al

Biochemistry. Vol. 56 (16), p. 2170-2174

Journal article

2017

A nano flow cytometer for single lipid vesicle analysis

R. Friedrich, Stephan Block, Mohammadreza Alizadehheidari et al

Lab on a Chip - Miniaturisation for Chemistry and Biology. Vol. 17 (5), p. 830-841

Journal article

2017

Lipid membranes catalyse the fibril formation of the amyloid-? (1–42) peptide through lipid-fibril interactions that reinforce secondary pathways

David Lindberg, Emelie Vilhelmsson Wesén, Johan Björkeroth et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1859 (10), p. 1921-1929

Journal article

2016

Detection of amyloid-beta fibrils using the DNA-intercalating dye YOYO-1: Binding mode and fibril formation kinetics

David Lindberg, Elin Esbjörner Winters

Biochemical and Biophysical Research Communications. Vol. 469 (2), p. 313-318

Journal article

2015

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

P. Aran Terol, J.R. Kumita, S.C. Hook et al

Biochemical and Biophysical Research Communications. Vol. 468 (4), p. 696-701

Journal article

2015

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by A beta(1-40) and A beta(1-42)

David Lindberg, Moa Sandberg Wranne, Melina Gilbert Gatty et al

Biochemical and Biophysical Research Communications. Vol. 458 (2), p. 418-423

Journal article

2015

Time-resolved thioflavin-T fluorescence-expanding the amyloid characterisation toolbox

David Lindberg, Elin Esbjörner Winters

FEBS Journal. Vol. 282, p. 178-179

Other conference contribution

2014

Direct Observations of Amyloid beta Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of A beta(1-40) and A beta(1-42) Aggregation

Elin Esbjörner Winters, F. Chan, E. Rees et al

Chemistry and Biology. Vol. 21 (6), p. 732-742

Journal article

2014

Studying Distribution and Aggregation of TDP-43 in Mammalian Cells: A Comparison between Fluorescent Protein and Tetracysteine Labelling Strategies

J. S. W. Ng, T. P. Barros, Elin Esbjörner Winters et al

Biophysical Journal. Vol. 106 (2), p. 458A-458A

Magazine article

2012

Effects of Tryptophan Content and Backbone Spacing on the Uptake Efficiency of Cell-Penetrating Peptides

Hanna Rydberg, Maria Matson, Helene Åmand et al

Biochemistry. Vol. 51 (27), p. 5531-5539

Journal article

2012

Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans

Helene Åmand, Hanna Rydberg, Louise Fornander et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1818 (11), p. 2669-2678

Journal article

2010

Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery

X. A. Zhang, K. Oglecka, S. Sandgren et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1798 (12), p. 2201-2208

Journal article

2009

Assigning Membrane Binding Geometry of Cytochrome c by Polarized Light Spectroscopy

Christina Hagelin, Elin Esbjörner Winters, Per Lincoln et al

Biophysical Journal. Vol. 96 (8), p. 3399-3411

Journal article

2008

DNA condensation by PAMAM dendrimers: Self-assembly characteristics and effect on transcription

Kristina Fant, Elin Esbjörner Winters, Per Lincoln et al

Biochemistry. Vol. 47 (6), p. 1732-1740

Journal article

2008

Stimulated endocytosis in penetratin uptake: Effect of arginine and lysine

Helene Åmand, Kristina Fant, Bengt Nordén et al

Biochemical and Biophysical Research Communications. Vol. 371 (4), p. 621-625

Journal article

2007

Tryptophan Orientation in Model Lipid Membranes

Elin Esbjörner Winters, Christina Hagelin, Bo Albinsson et al

Biochemical and Biophysical Research Communications. Vol. 361 (3), p. 645-650

Journal article

2007

Membrane-Active Peptides for Drug Delivery: Positioning, Structure and Interactions in Model Membranes

Elin Esbjörner Winters

Doctoral thesis

2007

Counterion-mediated Membrane Penetration: Cationic Cell-penetrating Peptides overcome Born Energy Barrier by Ion-pairing with Phospholipids

Elin Esbjörner Winters, Per Lincoln, Bengt Nordén

Biochimica et Biophysica Acta (BBA) - Biomembranes. Vol. 1768 (6), p. 1550-1558

Journal article

2007

Membrane binding of pH-sensitive influenza fusion peptides. Positioning, configuration, and induced leakage in a lipid vesicle model

Elin Esbjörner Winters, K. Oglecka, Per Lincoln et al

Biochemistry. Vol. 46 (47), p. 13490-13504

Journal article

2007

Retinoid chromophores as probes of membrane lipid order

Frida Svensson, Per Lincoln, Bengt Nordén et al

Journal of Physical Chemistry B. Vol. 111 (36), p. 10839-10848

Journal article

2007

Membrane Interactions of Cell-Penetrating Peptides

Bengt Nordén, Elin Esbjörner Winters, Astrid Gräslund

Handbook of cell-Penetrating Peptides, p. 109-137

Book chapter

2006

Membrane interactions of cell-penetrating peptides probed by tryptophan fluorescence and dichroism techniques: Correlations of structure to cellular uptake

Christina Hagelin, Elin Esbjörner Winters, Per Lincoln et al

Biochemistry. Vol. 45 (24), p. 7682-7692

Journal article

2005

Membrane interaction properties of cell-penetrating peptides

Elin Esbjörner Winters

Licentiate thesis

2004

Membrane binding and translocation of cell-penetrating peptides

Per Thoren, Daniel Persson, Elin Esbjörner Winters et al

Biochemistry. Vol. 43 (12), p. 3471-3489

Journal article

2004

Vesicle size-dependent translocation of penetratin analogs across lipid membranes

Daniel Persson, Per Thoren, Elin Esbjörner Winters et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1665 (1-2), p. 142-155

Journal article

2003

Meso stereoisomer as a probe of enantioselective threading intercalation of semirigid ruthenium complex [µ-(11,11'-bidppz)(phen)4Ru2]4+

Marcus Wilhelmsson, Elin Esbjörner Winters, Fredrik Westerlund et al

Journal of Physical Chemistry B. Vol. 107 (42), p. 11784-11793

Journal article

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Showing 14 research projects

2023–2028

Nanochannel Microscopy for Single Exosome Analysis