Elin Esbjörner Winters

Associate Professor at Chemical Biology

Elin Esbjörner is Associate Professor of Chemical Biology. Her research group studies protein misfolding and amyloid formation phenomena related to neurodegenerative diseases, using a combination of in vitro biophysics methods and cell biological approaches, including fluorescence microscopies and live cell imaging. The group focuses on how amyloid proteins interact with cells and cellular membranes, on their cell uptake and trafficking mechanisms, as well as on how different biological and pharmacological modulators affect the amyloid formation process. Elin is also a Principle Investigation in the FoRmulaEx research centre for functional RNA delivery, where her group collaborates extensively with chemists and physicists to explore fundamental mechanisms for effective cellular uptake (endocytosis) and cytosolic delivery of nucleic-acid based drugs. Within this consortium, Elin’s group also contributes to the development of new fluorescent probes and bioanalytical methods to explore the interaction of drug delivery vectors with cells.

Esbjörner Winters Research Group


Full list of publications

Source: chalmers.se
Image of Elin Esbjörner Winters

Showing 38 publications

2020

Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

Quentin Lubart, Jonas Hannestad, Hudson Pace et al
Physical Chemistry Chemical Physics. Vol. 22 (16), p. 8781-8790
Journal article
2020

Amyloid formation of bovine insulin is retarded in moderately acidic pH and by addition of short-chain alcohols

David Bernson, Almedina Basic, MD Tuhin Abed et al
European Biophysics Journal. Vol. 49 (2), p. 145-153
Journal article
2020

The Liver and Kidneys mediate clearance of cardiac troponin in the rat

Aida Muslimovic, Vincent Fridén, Olav Tenstad et al
Scientific Reports. Vol. 10 (1)
Journal article
2020

Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity

Xiaolu Zhang, Emelie Vilhelmsson Wesén, Ranjeet Kumar et al
ACS Chemical Neuroscience. Vol. 11 (3), p. 233-241
Journal article
2020

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

Quentin Lubart, Sune Levin, Stephan Block et al
Conference contribution
2020

Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer's Disease Peptide Aβ(1-42)

Emelie Vilhelmsson Wesén, Richard Lundmark, Elin Esbjörner Winters
ACS Chemical Neuroscience. Vol. 11 (13), p. 1925-1936
Journal article
2020

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro

Nima Sasanian, David Bernson, Istvan Horvath et al
Biomolecules. Vol. 10 (6), p. 1-19
Journal article
2019

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye to Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Janice S.W. Ng, Maya A. Hanspal, Naunehal S. Matharu et al
Biochemistry. Vol. 58 (39), p. 4086-4095
Journal article
2018

Copper Chaperone Atox1 Interacts with Cell Cycle Proteins

Maria Matson Dzebo, Stephanie Blockhuys, Sebastian Valenzuela et al
Computational and Structural Biotechnology Journal. Vol. 16, p. 443-449
Journal article
2018

Cell surface proteoglycan-mediated uptake and accumulation of the Alzheimer's disease peptide Aβ(1–42)

Emelie Vilhelmsson Wesén, Audrey Gallud, Alexandra Paul et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1860 (11), p. 2204-2214
Journal article
2017

Lipid membranes catalyse the fibril formation of the amyloid-? (1–42) peptide through lipid-fibril interactions that reinforce secondary pathways

David Lindberg, Emelie Vilhelmsson Wesén, Johan Björkeroth et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1859 (10), p. 1921-1929
Journal article
2017

Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40)

Emelie Vilhelmsson Wesén, Gavin Jeffries, Maria Matson Dzebo et al
Scientific Reports. Vol. 7 (1)
Journal article
2017

A nano flow cytometer for single lipid vesicle analysis

R. Friedrich, Stephan Block, Mohammadreza Alizadehheidari et al
Lab on a Chip - Miniaturisation for Chemistry and Biology. Vol. 17 (5), p. 830-841
Journal article
2017

Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction

David Lindberg, Anna Wenger, Elin Sundin et al
Biochemistry. Vol. 56 (16), p. 2170-2174
Journal article
2016

Detection of amyloid-beta fibrils using the DNA-intercalating dye YOYO-1: Binding mode and fibril formation kinetics

David Lindberg, Elin Esbjörner Winters
Biochemical and Biophysical Research Communications. Vol. 469 (2), p. 313-318
Journal article
2015

Time-resolved thioflavin-T fluorescence-expanding the amyloid characterisation toolbox

David Lindberg, Elin Esbjörner Winters
FEBS Journal. Vol. 282, p. 178-179
Conference contribution
2015

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by A beta(1-40) and A beta(1-42)

David Lindberg, Moa Sandberg Wranne, Melina Gilbert Gatty et al
Biochemical and Biophysical Research Communications. Vol. 458 (2), p. 418-423
Journal article
2015

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

P. Aran Terol, J.R. Kumita, S.C. Hook et al
Biochemical and Biophysical Research Communications. Vol. 468 (4), p. 696-701
Journal article
2014

Studying Distribution and Aggregation of TDP-43 in Mammalian Cells: A Comparison between Fluorescent Protein and Tetracysteine Labelling Strategies

J. S. W. Ng, T. P. Barros, Elin Esbjörner Winters et al
Biophysical Journal. Vol. 106 (2), p. 458A-458A
Magazine article
2014

Direct Observations of Amyloid beta Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of A beta(1-40) and A beta(1-42) Aggregation

Elin Esbjörner Winters, F. Chan, E. Rees et al
Chemistry and Biology. Vol. 21 (6), p. 732-742
Journal article
2012

Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans

Helene Åmand, Hanna Rydberg, Louise Fornander et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1818 (11), p. 2669-2678
Journal article
2012

Effects of Tryptophan Content and Backbone Spacing on the Uptake Efficiency of Cell-Penetrating Peptides

Hanna Rydberg, Maria Matson, Helene Åmand et al
Biochemistry. Vol. 51 (27), p. 5531-5539
Journal article
2010

Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery

X. A. Zhang, K. Oglecka, S. Sandgren et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1798 (12), p. 2201-2208
Journal article
2009

Assigning Membrane Binding Geometry of Cytochrome c by Polarized Light Spectroscopy

Christina Hagelin, Elin Esbjörner Winters, Per Lincoln et al
Biophysical Journal. Vol. 96 (8), p. 3399-3411
Journal article
2008

Stimulated endocytosis in penetratin uptake: Effect of arginine and lysine

Helene Åmand, Kristina Fant, Bengt Nordén et al
Biochemical and Biophysical Research Communications. Vol. 371 (4), p. 621-625
Journal article
2008

DNA condensation by PAMAM dendrimers: Self-assembly characteristics and effect on transcription

Kristina Fant, Elin Esbjörner Winters, Per Lincoln et al
Biochemistry. Vol. 47 (6), p. 1732-1740
Journal article
2007

Membrane binding of pH-sensitive influenza fusion peptides. Positioning, configuration, and induced leakage in a lipid vesicle model

Elin Esbjörner Winters, K. Oglecka, Per Lincoln et al
Biochemistry. Vol. 46 (47), p. 13490-13504
Journal article
2007

Membrane Interactions of Cell-Penetrating Peptides

Bengt Nordén, Elin Esbjörner Winters, Astrid Gräslund
Handbook of cell-Penetrating Peptides, p. 109-137
Book chapter
2007

Retinoid chromophores as probes of membrane lipid order

Frida Svensson, Per Lincoln, Bengt Nordén et al
Journal of Physical Chemistry B. Vol. 111 (36), p. 10839-10848
Journal article
2007

Tryptophan Orientation in Model Lipid Membranes

Elin Esbjörner Winters, Christina Hagelin, Bo Albinsson et al
Biochemical and Biophysical Research Communications. Vol. 361 (3), p. 645-650
Journal article
2007

Counterion-mediated Membrane Penetration: Cationic Cell-penetrating Peptides overcome Born Energy Barrier by Ion-pairing with Phospholipids

Elin Esbjörner Winters, Per Lincoln, Bengt Nordén
Biochimica et Biophysica Acta (BBA) - Biomembranes. Vol. 1768 (6), p. 1550-1558
Journal article
2006

Membrane interactions of cell-penetrating peptides probed by tryptophan fluorescence and dichroism techniques: Correlations of structure to cellular uptake

Christina Hagelin, Elin Esbjörner Winters, Per Lincoln et al
Biochemistry. Vol. 45 (24), p. 7682-7692
Journal article
2005

Membrane interaction properties of cell-penetrating peptides

Elin Esbjörner Winters
Licentiate thesis
2004

Membrane binding and translocation of cell-penetrating peptides

Per Thoren, Daniel Persson, Elin Esbjörner Winters et al
Biochemistry. Vol. 43 (12), p. 3471-3489
Journal article
2004

Vesicle size-dependent translocation of penetratin analogs across lipid membranes

Daniel Persson, Per Thoren, Elin Esbjörner Winters et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1665 (1-2), p. 142-155
Journal article
2003

Meso stereoisomer as a probe of enantioselective threading intercalation of semirigid ruthenium complex [µ-(11,11'-bidppz)(phen)4Ru2]4+

Marcus Wilhelmsson, Elin Esbjörner Winters, Fredrik Westerlund et al
Journal of Physical Chemistry B. Vol. 107 (42), p. 11784-11793
Journal article

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Showing 8 research projects

2019–2022

The role of lipid droplets in neurodegeneration studied in cells using advanced microscopy

Alexandra Paul Chemical Biology
Elin Esbjörner Winters Chemical Biology
Swedish Research Council (VR)

2019–2021

Role of TDP-43 accumulation and prion-like propagation in ALS: insights from a new fluorescent cell model

Elin Esbjörner Winters Chemical Biology
Ulla-Carin Lindquist stiftelse för ALS-forskning

2019–2021

Improved resolution in imaging of amyloid fibrils using non-covalent fluorescent dyes

Elin Esbjörner Winters Chemical Biology
Magnus Bergvalls Stiftelse

2019–2021

Mechanistic studies of prion-like propagation and inclusion formation of TDP-43 in a cell model of ALS

Elin Esbjörner Winters Chemical Biology
Åhlén-stiftelsen

2017–2024

Funktionell leverans av nukleotid-baserade läkemedel

Fredrik Höök Biological Physics
Marcus Wilhelmsson Chemistry and Biochemistry
Elin Esbjörner Winters Chemical Biology
Swedish Foundation for Strategic Research (SSF)

2017–2020

Vad karaktäriserar en toxisk amyloid oligomer?

Elin Esbjörner Winters Chemical Biology
Swedish Research Council (VR)

2012–2015

Identification of Cellular Targets for Amyloid Beta Toxicity in Alzheimers Disease

Elin Esbjörner Winters Chemical Biology
VINNOVA

There might be more projects where Elin Esbjörner Winters participates, but you have to be logged in as a Chalmers employee to see them.