OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort
Journal article, 2024

Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from the Swedish Mammography Cohort - Clinical (n = 657 subjects). OCs, PFAS, and multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma. POP-related omics features were selected using random forest followed by Spearman correlation adjusted for confounders. From these, CVD-related omics features were selected using conditional logistic regression. Finally, 29 (for OCs) and 12 (for PFAS) unique features associated with POPs and CVD. One omics subpattern, driven by lipids and inflammatory proteins, associated with MI (OR = 2.03; 95% CI = 1.47; 2.79), OCs, age, and BMI, and correlated negatively with PFAS. Another subpattern, driven by carnitines, associated with stroke (OR = 1.55; 95% CI = 1.16; 2.09), OCs, and age, but not with PFAS. This may imply that OCs and PFAS associate with different omics patterns with opposite effects on CVD risk, but more research is needed to disentangle potential modifications by other factors.


cardiovascular disease

nested case-control study



persistent organic pollutants



Tessa Schillemans

Karolinska Institutet

Yingxiao Yan

Chalmers, Life Sciences, Food and Nutrition Science

Anton Ribbenstedt

Chalmers, Life Sciences, Systems and Synthetic Biology

Carolina Donat Vargas

University of Barcelona

Karolinska Institutet

Christian H. Lindh

Lund University

Hannu Kiviranta

National Institute for Health and Welfare

Panu Rantakokko

National Institute for Health and Welfare

Alicja Wolk

Karolinska Institutet

Rikard Landberg

Chalmers, Life Sciences, Food and Nutrition Science

Umeå University

Agneta Åkesson

Karolinska Institutet

Carl Brunius

Uppsala University

Chalmers, Life Sciences, Food and Nutrition Science

Environmental Science & Technology

0013-936X (ISSN) 1520-5851 (eISSN)

Vol. 58 2 1036-1047

Subject Categories

Environmental Health and Occupational Health





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2/2/2024 7