Topographically Flat Nanoplasmonic Sensor Chips for Biosensing and Materials Science
Journal article, 2017

Nanoplasmonic sensors typically comprise arrangements of noble metal nanoparticles on a dielectric support. Thus they are intrinsically characterized by surface topography with corrugations at the 10–100 nm length scale. While irrelevant in some bio- and chemosensing applications, it is also to be expected that the surface topography significantly influences the interaction between solids, fluids, nanoparticles and (bio)molecules, and the nanoplasmonic sensor surface. To address this issue, we present a wafer-scale nanolithography-based fabrication approach for high-temperature compatible, chemically inert and topographically flat and laterally homogeneous nanoplasmonic sensor chips. We demonstrate their sensing performance on three different examples, for which we also carry out a direct comparison with a traditional nanoplasmonic sensor with representative surface corrugation. Specifically, we (i) quantify the film-thickness dependence of the glass transition temperature in poly(methyl metacrylate) thin films, (ii) characterize the adsorption and specific binding kinetics of the avidin – b-BSA protein system and (iii) analyze supported lipid bilayer formation on SiO2 surfaces.

avidin adsorption

nanoplasmonic sensing (NPS)

b-BSA specific binding

flat topography

supported lipid bilayer formation

polymer glass transition

surface corrugation


Ferry Nugroho

Chalmers, Physics, Chemical Physics

Rickard Frost

Chalmers, Physics, Chemical Physics

Tomasz Antosiewicz

Chalmers, Physics, Bionanophotonics

Joachim Fritzsche

Chalmers, Physics, Chemical Physics

Elin Maria Kristina Larsson


Christoph Langhammer

Chalmers, Physics, Chemical Physics

ACS Sensors

2379-3694 (eISSN)

Vol. 2 1 119-127

Subject Categories

Atom and Molecular Physics and Optics

Condensed Matter Physics



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4/5/2022 1