A biohybrid dynamic random access memory
Journal article, 2006

We report that GABA(A) receptors in a patch-clamped biological cell form a short-term memory circuit when integrated with a scanning-probe microfluidic device. Laminar patterns of receptor activators (agonists) provided by the microfluidic device define and periodically update the data input which is read and stored by the receptors as state distributions (based on intrinsic multistate kinetics). The memory is discharged over time and lasts for seconds to minutes depending on the input function. The function of the memory can be represented by an equivalent electronic circuit with striking similarity in function to a dynamic random access memory (DRAM) used in electronic computers. Multiplexed biohybrid memories may form the basis of large-scale integrated biocomputational/sensor devices with the curious ability to use chemical signals including odorants, neurotransmitters, chemical and biological warfare agents, and many more as input signals.

Author

J. Sinclair

Chalmers

D. Granfeldt

Chalmers

Johan Pihl

Cellectricon AB

Maria Millingen

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Per Lincoln

Chalmers, Chemical and Biological Engineering, Physical Chemistry

C. Farre

Cellectricon AB

Lena Peterson

Chalmers, Signals and Systems, Signalbehandling och medicinsk teknik, Signal Processing

Owe Orwar

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Journal of the American Chemical Society

0002-7863 (ISSN) 1520-5126 (eISSN)

Vol. 128 15 5109-5113

Subject Categories

Chemical Sciences

DOI

10.1021/ja0580993

More information

Latest update

9/10/2018