Saccharomyces cerevisiae Spore Germination
Kapitel i bok, 2010
Saccharomyces cerevisiae spore germination is the process in which
dormant spores resume growth. Upon exposure to glucose and other essential
nutrients, the spore gradually loses its spore characteristics and starts acquiring
properties of a vegetative cell. Translation and transcription are initiated early in the
germination process. Global gene expression analysis has revealed that germination
can be divided into two stages prior to the first cell cycle. During the first stage, the
transcriptional programme resembles the general response of yeast cells to glucose.
During the second stage, the spores sense and respond also to other nutrients than
glucose. In addition, genes involved in conjugation are upregulated in germinating
spores and mating is initiated before the first mitotic cell cycle. Here, we review the
current understanding of the cellular rearrangements and the genes and proteins
involved in germination.