Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening
Artikel i vetenskaplig tidskrift, 2011

Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)2NO3], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)2]NO3 . H2O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)o. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0o. Compound I was characterized by 1H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml-1, respectively). Three different hydrogels containing I or Ag2SO4 were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself.

ag-i

bonding complexes

metal-complexes

antimicrobial activity

crystal-structures

deoxyribonucleic acid

fe-iii

ag(i) complexes

zn-ii

cu-ii

Författare

Al-Shimaà A A Massoud

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Y. M. Gohar

Alexandria University

Vratislav Langer

Chalmers, Kemi- och bioteknik, Oorganisk miljökemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Frida Svensson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

J. Janis

Itä-Suomen Yliopisto

Sofie Gårdebjer

Chalmers

M. Haukka

Itä-Suomen Yliopisto

Fabian Jonsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Emma Aneheim

Chalmers, Kemi- och bioteknik, Kärnkemi

P. Lowenhielm

Morsy A. M. Abu-Youssef

Alexandria University

Lars Öhrström

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

New Journal of Chemistry

1144-0546 (ISSN) 1369-9261 (eISSN)

Vol. 35 3 640-648

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Kemi

DOI

10.1039/c0nj00697a

Mer information

Senast uppdaterat

2018-09-10