Pore Spanning Lipid Bilayers on Mesoporous Silica Having Varying Pore Size
Artikel i vetenskaplig tidskrift, 2011

Synthetic lipid bilayers have similar properties as cell membranes and have been shown to be of great use in the development of novel biomimicry devices. In this study, lipid bilayer formation on mesoporous silica of varying pore size, 2, 4, and 6 nm, has been investigated using quartz crystal microbalance with dissipation monitoring (QCM-D), fluorescent recovery after photo bleaching (FRAP), and atomic force microscopy (AFM). The results show that pore-spanning lipid bilayers were successfully formed regardless of pore size. However, the mechanism of the bilayer formation was dependent on the pore size, and lower surface coverages of adsorbed lipid vesicles were required on the surface having the smallest pores. A similar trend was observed for the lateral diffusion coefficient (D) of fluorescently labeled lipid molecules in the membrane, which was lowest on the surface having the smallest pores and increased with the pore size. All of the pore size dependent observations are suggested to be due to the hydrophilicity of the surface, which decreases with increased pore size.

mm lk

supported phospholipid-bilayers

membranes

v47

quartz-crystal microbalance

assemblies

1985

vesicle adsorption

atomic-force microscopy

porous silicon

p105

substrate

transport

thin-films

Författare

Maria Wallin

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Rickard Frost

Chalmers, Teknisk fysik, Biologisk fysik

Sofia Svedhem

Chalmers, Teknisk fysik, Biologisk fysik

Martin Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Langmuir

0743-7463 (ISSN) 1520-5827 (eISSN)

Vol. 27 8974-8982

Ämneskategorier

Kemi

Styrkeområden

Materialvetenskap

DOI

10.1021/la201411b