Pore Spanning Lipid Bilayers on Mesoporous Silica Having Varying Pore Size
Journal article, 2011

Synthetic lipid bilayers have similar properties as cell membranes and have been shown to be of great use in the development of novel biomimicry devices. In this study, lipid bilayer formation on mesoporous silica of varying pore size, 2, 4, and 6 nm, has been investigated using quartz crystal microbalance with dissipation monitoring (QCM-D), fluorescent recovery after photo bleaching (FRAP), and atomic force microscopy (AFM). The results show that pore-spanning lipid bilayers were successfully formed regardless of pore size. However, the mechanism of the bilayer formation was dependent on the pore size, and lower surface coverages of adsorbed lipid vesicles were required on the surface having the smallest pores. A similar trend was observed for the lateral diffusion coefficient (D) of fluorescently labeled lipid molecules in the membrane, which was lowest on the surface having the smallest pores and increased with the pore size. All of the pore size dependent observations are suggested to be due to the hydrophilicity of the surface, which decreases with increased pore size.

mm lk

1985

transport

substrate

v47

assemblies

supported phospholipid-bilayers

porous silicon

atomic-force microscopy

membranes

p105

thin-films

vesicle adsorption

quartz-crystal microbalance

Author

Maria Claesson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Rickard Frost

Chalmers, Applied Physics, Biological Physics

Sofia Svedhem

Chalmers, Applied Physics, Biological Physics

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Langmuir

0743-7463 (ISSN) 1520-5827 (eISSN)

Vol. 27 14 8974-8982

Subject Categories

Chemical Sciences

Areas of Advance

Materials Science

DOI

10.1021/la201411b

More information

Latest update

11/5/2018