Mathematical models of cell factories: moving towards the core of industrial biotechnology
Artikel i vetenskaplig tidskrift, 2011

Industrial biotechnology involves the utilization of cell factories for the production of fuels and chemicals. Traditionally, the development of highly productive microbial strains has relied on random mutagenesis and screening. The development of predictive mathematical models provides a new paradigm for the rational design of cell factories. Instead of selecting among a set of strains resulting from random mutagenesis, mathematical models allow the researchers to predict in silico the outcomes of different genetic manipulations and engineer new strains by performing gene deletions or additions leading to a higher productivity of the desired chemicals. In this review we aim to summarize the main modelling approaches of biological processes and illustrate the particular applications that they have found in the field of industrial microbiology.

thermodynamic feasibility

osmotic-stress

corynebacterium-glutamicum

complex metabolic networks

approximation

biochemical systems analysis

escherichia-coli

analysis

power-law

saccharomyces-cerevisiae

pathway

fission yeast

Författare

Marija Cvijovic

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Sergio Velasco

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Jens B Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Microbial Biotechnology

1751-7907 (ISSN)

Vol. 4 5 572-584

Ämneskategorier

Industriell bioteknik

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1111/j.1751-7915.2010.00233.x

Mer information

Skapat

2017-10-08