Mathematical models of cell factories: moving towards the core of industrial biotechnology
Artikel i vetenskaplig tidskrift, 2011
Industrial biotechnology involves the utilization of cell factories for the production of fuels and chemicals. Traditionally, the development of highly productive microbial strains has relied on random mutagenesis and screening. The development of predictive mathematical models provides a new paradigm for the rational design of cell factories. Instead of selecting among a set of strains resulting from random mutagenesis, mathematical models allow the researchers to predict in silico the outcomes of different genetic manipulations and engineer new strains by performing gene deletions or additions leading to a higher productivity of the desired chemicals. In this review we aim to summarize the main modelling approaches of biological processes and illustrate the particular applications that they have found in the field of industrial microbiology.
thermodynamic feasibility
osmotic-stress
corynebacterium-glutamicum
complex metabolic networks
approximation
biochemical systems analysis
escherichia-coli
analysis
power-law
saccharomyces-cerevisiae
pathway
fission yeast
Författare
Marija Cvijovic
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Sergio Velasco
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Jens B Nielsen
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Microbial Biotechnology
1751-7907 (ISSN) 17517915 (eISSN)
Vol. 4 5 572-584Ämneskategorier
Industriell bioteknik
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1111/j.1751-7915.2010.00233.x