Does ketoprofen or diclofenac pose the lowest risk to fish?
Artikel i vetenskaplig tidskrift, 2012

Ketoprofen and diclofenac are non-steroidal anti-inflammatory drugs (NSAIDs) often used for similar indications, and both are frequently found in surface waters. Diclofenac affects organ histology and gene expression in fish at around 1 mu g/L. Here, we exposed rainbow trout to ketoprofen (1, 10 and 100 mu g/L) to investigate if this alternative causes less risk for pharmacological responses in fish. The bioconcentration factor from water to fish blood plasma was <0.05(4 for diclofenac based on previous studies). Ketoprofen only reached up to 0.6 parts per thousand of the human therapeutic plasma concentration, thus the probability of target-related effects was estimated to be fairly low. Accordingly, a comprehensive analysis of hepatic gene expression revealed no consistent responses. In some contrast, trout exposed to undiluted, treated sewage effluents bioconcentrated ketoprofen and other NSAIDs much more efficiently, according to a meta-analysis of recent studies. Neither of the setups is however an ideal representation of the field situation. If a controlled exposure system with a single chemical in pure water is a reasonable representation of the environment, then the use of ketoprofen is likely to pose a lower risk for wild fish than diclofenac, but if bioconcentration factors from effluent-exposed fish are applied, the risks may be more similar.

drugs

human

trout oncorhynchus-mykiss

sewage effluents

Bioconcentration

pharmaceuticals

bioconcentration

NSAID

rainbow-trout

Ketoprofen

bioaccumulation

Fish

blood-plasma

Gene expression

hepatic gene-expression

liver

Författare

Filip Cuklev

Göteborgs universitet

J. Fick

Umeå universitet

Marija Cvijovic

Chalmers, Matematiska vetenskaper, Matematik

Göteborgs universitet

Erik Kristiansson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Lars Förlin

Göteborgs universitet

D. G. Joakim Larsson

Göteborgs universitet

Journal of Hazardous Materials

0304-3894 (ISSN)

Vol. 229-230 100-106

Ämneskategorier

Annan medicin och hälsovetenskap

DOI

10.1016/j.jhazmat.2012.05.077