Charged microcapsules for controlled release of hydrophobic actives. Part III: The effect of polyelectrolyte brush- and multilayers on sustained release
Artikel i vetenskaplig tidskrift, 2013

Poly(methyl methacrylate) microspheres have been prepared by the internal phase separation method using either of the three conventional dispersants poly(vinyl alcohol) (PVA), poly(methacrylic acid) (PMAA), or the amphiphilic block copolymer poly(methyl methacrylate)-block-poly(sodium methacrylate). The block copolymer based microsphere, which has a polyelectrolyte brush on the surface, was surface modified with up to two poly(diallyldimethylammonium chloride)-poly(sodium methacrylate) bilayers. The microspheres were loaded with the hydrophobic dye 2-(4-(2-chloro-4-nitrophenylazo)-N-ethylphenylamino)ethanol (Disperse Red 13) and its release from aqueous dispersions of microspheres with the different surface compositions was measured by spectrophotometry. The burst fraction, burst rate and the diffusion constant were determined from a model combining burst and diffusive release. Out of the three dispersants, the block copolymer gave the slowest release of the dye, with respect to both burst release and diffusive release. A very pronounced further reduction of the diffusion constant was obtained by applying polyelectrolyte multilayers on top of the microspheres. However, the diffusion constant was very weakly dependent on further polyelectrolyte adsorption and one polyelectrolyte bilayer appeared to suffice.

Författare

Markus Andersson Trojer

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Helena Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Ye Li

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Jonatan Bergek

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Krister Holmberg

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Magnus Nydén

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

SuMo Biomaterials

Lars Nordstierna

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Physical Chemistry Chemical Physics

1463-9076 (ISSN) 1463-9084 (eISSN)

Vol. 15 17 6153-6165

Ämneskategorier

Fysikalisk kemi

Styrkeområden

Materialvetenskap

DOI

10.1039/c3cp50417d