A maternal diet of fatty fish reduces body fat of offspring compared with a maternal diet of beef and a post-weaning diet of fish improves insulin sensitivity and lipid profile in adult C57BL/6 male mice.
Artikel i vetenskaplig tidskrift, 2013

Aim The maternal diet during pregnancy and lactation may affect the long-term health of the offspring. Our aim was to study how a fish or meat diet perinatal and after weaning affects body composition, insulin sensitivity and the profile of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in breast milk, fat depots, skeletal muscle and liver in male adult mice offspring. Methods During gestation and lactation, C57BL/6 dams were fed a herring- or beef-based diet. Half of the pups in each group changed diets after weaning. In offspring, body composition measured by DEXA, plasma lipid profile and insulin sensitivity measured by euglycemic clamp or QUICKI were monitored to adulthood. Analysis of total FAs by GC-MS were performed in the diet, breast milk and in different tissues. Results At 9 week of age, offspring of herring-fed dams had less body fat than offspring of beef-fed dams. Mice fed herring after weaning had increased insulin sensitivity at 15 week of age, reduced total plasma cholesterol and triglyceride levels, and compared with beef-fed mice, larger interscapular brown adipose tissue depots. The FA composition of the maternal diet was mirrored in breast milk, and the herring diet significantly affected the FA profile of different tissues, leading to an increased content of n-3 PUFAs. Conclusion A herring-based maternal diet reduces body fat in the offspring, but the insulin sensitivity, plasma lipids and amount of brown adipose tissue are affected by the offspring's own diet; the herring diet is more beneficial than the beef diet.

insulin sensitivity

fatty fish

red meat

maternal diet

body composition

n-6/n-3 ratio

Författare

Ahmed Hussain

Göteborgs universitet

Intawat Nookaew

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Sakda Khoomrung

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

L. Andersson

Göteborgs universitet

Ingrid Larsson

Sahlgrenska Universitetssjukhuset

Lena Hulthén

Göteborgs universitet

Nina Jansson

Göteborgs universitet

Robert Jakubowicz

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Ann-Sofie Sandberg

Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Jens B Nielsen

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Agneta Holmäng

Göteborgs universitet

Acta Physiologica

1748-1708 (ISSN) 1748-1716 (eISSN)

Vol. 209 220-234

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Näringslära

DOI

10.1111/apha.12130