Microwave-Based Stroke Diagnosis Making Global Prehospital Thrombolytic Treatment Possible
Artikel i vetenskaplig tidskrift, 2014

Here, we present two different brain diagnostic devices based on microwave technology and the associated two first proof-of-principle measurements that show that the systems can differentiate hemorrhagic from ischemic stroke in acute stroke patients, as well as differentiate hemorrhagic patients from healthy volunteers. The system was based on microwave scattering measurements with an antenna system worn on the head. Measurement data were analyzed with a machine-learning algorithm that is based on training using data from patients with a known condition. Computer tomography images were used as reference. The detection methodology was evaluated with the leave-one-out validation method combined with a Monte Carlo-based bootstrap step. The clinical motivation for this project is that ischemic stroke patients may receive acute thrombolytic treatment at hospitals, dramatically reducing or abolishing symptoms. A microwave system is suitable for prehospital use, and therefore has the potential to allow significantly earlier diagnosis and treatment than today.

Microwave system

subspace distance classification

stroke diagnostics

Författare

Mikael Persson

Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

Andreas Fhager

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

Hana Dobsicek Trefna

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

Yinan Yu

Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

Tomas McKelvey

Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

Göran Pegenius

Göteborgs universitet

Jan-Erik Karlsson

Sahlgrenska universitetssjukhuset

Mikael Elam

Göteborgs universitet

IEEE Transactions on Biomedical Engineering

0018-9294 (ISSN)

Vol. 61 2806-2817 6832574

Ämneskategorier

Fysiologi

DOI

10.1109/tbme.2014.2330554