Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease
Artikel i vetenskaplig tidskrift, 2020

Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.

metabolomics

metabotyping

targeted nutrition

personalized nutrition

precision nutrition

cardiometabolic diseases

gut microbiota

Författare

Marie Palmnäs

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Carl Brunius

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Lin Shi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Shaanxi Normal University

Agnetha Rostgaard-Hansen

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Danish Cancer Research Society Center

Núria Estanyol Torres

Instituto de Salud Carlos III

Universitat de Barcelona

Raúl González-Domínguez

Universitat de Barcelona

Instituto de Salud Carlos III

Raúl Zamora-Ros

Bellvitge Biomedical Research Institute IDIBELL

Universitat de Barcelona

Ling Qun Ye

Chalmers, Biologi och bioteknik, Systembiologi

Jytte Halkjær

Danish Cancer Research Society Center

Anne Tjønneland

Danish Cancer Research Society Center

Gabriele Riccardi

Universita degli Studi di Napoli Federico II

Rosalba Giacco

Universita degli Studi di Napoli Federico II

Consiglio Nazionale delle Ricerche (CNR)

Giuseppina Costabile

Universita degli Studi di Napoli Federico II

Claudia Vetrani

Universita degli Studi di Napoli Federico II

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Cristina Andres-Lacueva

Instituto de Salud Carlos III

Universitat de Barcelona

Rikard Landberg

Umeå universitet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Advances in nutrition (Bethesda, Md.)

2156-5376 (ISSN)

Vol. 11 3 524-532

Kost- och mikrobiombaserade metabotyper för bestämning av kardiometabol risk och för skräddarsydda interventionsstrategier för bättre hälsa

Formas, 2018-01-01 -- 2021-12-31.

Ämneskategorier

Biologiska vetenskaper

Hälsovetenskaper

Näringslära

DOI

10.1093/advances/nmz121

PubMed

31782487

Mer information

Senast uppdaterat

2020-07-30