Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease
Reviewartikel, 2020
Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.
precision nutrition
cardiometabolic diseases
personalized nutrition
metabotyping
metabolomics
gut microbiota
targeted nutrition
Författare
Marie Palmnäs
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Carl Brunius
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Lin Shi
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Shaanxi Normal University
Agnetha Rostgaard-Hansen
Danish Cancer Research Society Center
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Núria Estanyol-Torres
Universitat de Barcelona
Instituto de Salud Carlos III
Raúl González-Domínguez
Instituto de Salud Carlos III
Universitat de Barcelona
Raúl Zamora-Ros
Universitat de Barcelona
Bellvitge Biomedical Research Institute IDIBELL
Ling Qun Ye
Chalmers, Biologi och bioteknik, Systembiologi
Jytte Halkjær
Danish Cancer Research Society Center
Anne Tjønneland
Danish Cancer Research Society Center
Gabriele Riccardi
Universita degli Studi di Napoli Federico II
Rosalba Giacco
Universita degli Studi di Napoli Federico II
Consiglio Nazionale delle Ricerche (CNR)
Giuseppina Costabile
Universita degli Studi di Napoli Federico II
Claudia Vetrani
Universita degli Studi di Napoli Federico II
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
Cristina Andres-Lacueva
Universitat de Barcelona
Instituto de Salud Carlos III
Rikard Landberg
Umeå universitet
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Advances in nutrition (Bethesda, Md.)
21618313 (ISSN) 21565376 (eISSN)
Vol. 11 3 524-532Kost- och mikrobiombaserade metabotyper för bestämning av kardiometabol risk och för skräddarsydda interventionsstrategier för bättre hälsa
Formas (2017-02003), 2018-01-01 -- 2021-12-31.
Ämneskategorier (SSIF 2011)
Biologiska vetenskaper
Hälsovetenskaper
Näringslära
DOI
10.1093/advances/nmz121
PubMed
31782487