Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release
Reviewartikel, 2018

Chemical signaling strength during intercellular communication can be regulated by secretory cells through controlling the amount of signaling molecules that are released from a secretory vesicle during the exocytosis process. In addition, the chemical signal can also be influenced by the amount of neurotransmitters that is accumulated and stored inside the secretory vesicle compartment. Here, we present the development of analytical methodologies and cell model systems that have been applied in neuroscience research for gaining better insights into the biophysics and the molecular mechanisms, which are involved in the regulatory aspects of the exocytosis machinery affecting the output signal of chemical transmission at neuronal and neuroendocrine cells.

Artificial cells

Electrochemical cytometry

Chromaffin cell

Intracellular electrochemical cytometry

Amperometry

Quantal size

Exocytosis

Fusion pore

Författare

Hoda Mashadi Fathali

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Analytisk kemi

Ann-Sofie Cans

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Pflugers Archiv European Journal of Physiology

0031-6768 (ISSN) 1432-2013 (eISSN)

Vol. 470 125-134

Ämneskategorier

Cellbiologi

Immunologi

Cell- och molekylärbiologi

DOI

10.1007/s00424-017-2069-9