Advancing biotechnology with CRISPR/Cas9: recent applications and patent landscape
Artikel i vetenskaplig tidskrift, 2018

Clustered regularly interspaced short palindromic repeats (CRISPR) is poised to become one of the key scientific discoveries of the twenty-first century. Originating from prokaryotic and archaeal immune systems to counter phage invasions, CRISPR-based applications have been tailored for manipulating a broad range of living organisms. From the different elucidated types of CRISPR mechanisms, the type II system adapted from Streptococcus pyogenes has been the most exploited as a tool for genome engineering and gene regulation. In this review, we describe the different applications of CRISPR/Cas9 technology in the industrial biotechnology field. Next, we detail the current status of the patent landscape, highlighting its exploitation through different companies, and conclude with future perspectives of this technology.

Författare

Raphael Ferreira

Chalmers, Biologi och bioteknik, Systembiologi

Florian David

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Journal of Industrial Microbiology and Biotechnology

1367-5435 (ISSN) 1476-5535 (eISSN)

Vol. 45 7 467-480

Ämneskategorier

Produktionsteknik, arbetsvetenskap och ergonomi

Övrig annan teknik

Programvaruteknik

DOI

10.1007/s10295-017-2000-6

PubMed

29362972

Mer information

Senast uppdaterat

2018-08-23