Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: A randomised cross-over trial
Artikel i vetenskaplig tidskrift, 2019

Objective T o investigate whether a whole grain diet alters the gut microbiome and insulin sensitivity, as well as biomarkers of metabolic health and gut functionality.
Design 60 Danish adults at risk of developing metabolic syndrome were included in a randomised cross-over trial with two 8-week dietary intervention periods comprising whole grain diet and refined grain diet, separated by a washout period of =6 weeks. The response to the interventions on the gut microbiome composition and insulin sensitivity as well on measures of glucose and lipid metabolism, gut functionality, inflammatory markers, anthropometry and urine metabolomics were assessed.
Results 50 participants completed both periods with a whole grain intake of 179±50 g/day and 13±10 g/day in the whole grain and refined grain period, respectively. Compliance was confirmed by a difference in plasma alkylresorcinols (p<0.0001). Compared with refined grain, whole grain did not significantly alter glucose homeostasis and did not induce major changes in the faecal microbiome. Also, breath hydrogen levels, plasma short-chain fatty acids, intestinal integrity and intestinal transit time were not affected. The whole grain diet did, however, compared with the refined grain diet, decrease body weight (p<0.0001), serum inflammatory markers, interleukin (IL)-6 (p=0.009) and C-reactive protein (p=0.003). The reduction in body weight was consistent with a reduction in energy intake, and IL-6 reduction was associated with the amount of whole grain consumed, in particular with intake of rye. Conclusion C ompared with refined grain diet, whole grain diet did not alter insulin sensitivity and gut microbiome but reduced body weight and systemic lowgrade inflammation.

Författare

Henrik Munch Roager

Danmarks Tekniske Universitet (DTU)

Josef K. Vogt

Danmarks Tekniske Universitet (DTU)

M. Kristensen

Köpenhamns universitet

Lea B.S. Hansen

Danmarks Tekniske Universitet (DTU)

Sabine Ibrügger

Köpenhamns universitet

Rasmus B. Mærkedahl

Köpenhamns universitet

Martin I. Bahl

Danmarks Tekniske Universitet (DTU)

Mads Vendelbo Lind

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Köpenhamns universitet

Rikke L. Nielsen

Danmarks Tekniske Universitet (DTU)

Hanne Frøkiær

Köpenhamns universitet

Rikke J. Gøbel

Köpenhamns universitet

Rikard Landberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Susanne Brix

Danmarks Tekniske Universitet (DTU)

Jesper Holck

Danmarks Tekniske Universitet (DTU)

Anne S. Meyer

Danmarks Tekniske Universitet (DTU)

Morten H. Sparholt

Bispebjerg Hospital

Anders F. Christensen

Bispebjerg Hospital

Vera Carvalho

Danmarks Tekniske Universitet (DTU)

Bolette Hartmann

Köpenhamns universitet

Jens Juul Holst

Köpenhamns universitet

Jüri J. Rumessen

Amtssygehuset i Gentofte

Allan Linneberg

Rigshospitalet

Research Centre for Prevention and Health

Köpenhamns universitet

T. Sicheritz-Pontén

Danmarks Tekniske Universitet (DTU)

Marlene D. Dalgaard

Danmarks Tekniske Universitet (DTU)

Andreas Blennow

Köpenhamns universitet

Henrik L. Frandsen

Danmarks Tekniske Universitet (DTU)

S.G.R. Villas-Bôas

University of Auckland

Karsten Kristiansen

Köpenhamns universitet

H. Vestergaard

Köpenhamns universitet

Steno Diabetes Center

T. Hansen

Köpenhamns universitet

Claus T. Ekstrøm

Köpenhamns universitet

Christian Ritz

Köpenhamns universitet

Henrik Bjørn Nielsen

Danmarks Tekniske Universitet (DTU)

Clinical-Microbiomics A/S

O. B. Pedersen

Köpenhamns universitet

Ramneek Gupta

Danmarks Tekniske Universitet (DTU)

L. Lauritzen

Köpenhamns universitet

Tine Rask Licht

Danmarks Tekniske Universitet (DTU)

Gut

0017-5749 (ISSN) 1468-3288 (eISSN)

Vol. 68 1 83-93

Ämneskategorier

Annan klinisk medicin

Livsmedelsvetenskap

Näringslära

DOI

10.1136/gutjnl-2017-314786

Mer information

Senast uppdaterat

2019-01-07