Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
Artikel i vetenskaplig tidskrift, 2020

Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.

Författare

M. Vajrychova

Fakultní nemocnice Hradec Králové

Jaroslav Stráník

Fakultní nemocnice Hradec Králové

Kristýna Pimková

Univerzita Karlova

Fakultní nemocnice Hradec Králové

Malin Barman

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Rudolf Kukla

Fakultní nemocnice Hradec Králové

Petra Zedníková

University of Pardubice

Czech Academy of Sciences

Fakultní nemocnice Hradec Králové

Radka Bolehovská

Fakultní nemocnice Hradec Králové

Lenka Plíšková

Fakultní nemocnice Hradec Králové

Helena Hornychová

Fakultní nemocnice Hradec Králové

Ctirad Andrýs

Fakultní nemocnice Hradec Králové

V. Tambor

Fakultní nemocnice Hradec Králové

J. Lenco

Fakultní nemocnice Hradec Králové

Univerzita Karlova

Bo Jacobsson

Norwegian Institute of Public Health

Göteborgs universitet

Marian Kacerovský

Fakultní nemocnice Hradec Králové

Univerzita Karlova

Scientific Reports

2045-2322 (ISSN)

Vol. 10 1 17696

Ämneskategorier

Infektionsmedicin

Mikrobiologi inom det medicinska området

Reproduktionsmedicin och gynekologi

DOI

10.1038/s41598-020-74756-9

PubMed

33077789

Mer information

Senast uppdaterat

2020-11-16