Osseointegration and antibacterial effect of an antimicrobial peptide releasing mesoporous titania implant
Artikel i vetenskaplig tidskrift, 2021

Medical devices such as orthopedic and dental implants may get infected by bacteria, which results in treatment using antibiotics. Since antibiotic resistance is increasing in society there is a need of finding alternative strategies for infection control. One potential strategy is the use of antimicrobial peptides, AMPs. In this study, we investigated the antibiofilm effect of the AMP, RRP9W4N, using a local drug-delivery system based on mesoporous titania covered titanium implants. Biofilm formation was studied in vitro using a safranine biofilm assay and LIVE/DEAD staining. Moreover, we investigated what effect the AMP had on osseointegration of commercially available titanium implants in vivo, using a rabbit tibia model. The results showed a sustained release of AMP with equal or even better antibiofilm properties than the traditionally used antibiotic Cloxacillin. In addition, no negative effects on osseointegration in vivo was observed. These combined results demonstrate the potential of using mesoporous titania as an AMP delivery system and the potential use of the AMP RRP9W4N for infection control of osseointegrating implants.

biofilm

Staphylococcus epidermidis

sustained release

rabbit tibia model

Författare

Maria Pihl

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

Silvia Galli

Malmö universitet

Ryo Jimbo

Malmö universitet

Martin Andersson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Martin Andersson Group

Journal of Biomedical Materials Research - Part B Applied Biomaterials

1552-4973 (ISSN)

Vol. In Press

Ämneskategorier

Infektionsmedicin

Biomaterialvetenskap

Medicinska material och protesteknik

DOI

10.1002/jbm.b.34838

Mer information

Senast uppdaterat

2021-05-03