Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
Artikel i vetenskaplig tidskrift, 2021

COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.

proteomics

metabolomics

combined metabolic activators

omics data

COVID-19

Författare

Ozlem Altay

University of Health Sciences

Kungliga Tekniska Högskolan (KTH)

Muhammad Arif

Kungliga Tekniska Högskolan (KTH)

Xiangyu Li

Kungliga Tekniska Högskolan (KTH)

Hong Yang

Kungliga Tekniska Högskolan (KTH)

Mehtap Aydın

University of Health Sciences

Gizem Alkurt

University of Health Sciences

Woonghee Kim

Kungliga Tekniska Högskolan (KTH)

Dogukan Akyol

University of Health Sciences

C. Zhang

Zhengzhou University

Kungliga Tekniska Högskolan (KTH)

Gizem Dinler-Doganay

Istanbul Teknik Universitesi (ITÜ)

Hasan Turkez

Atatürk Üniversitesi

Saeed Shoaie

Kungliga Tekniska Högskolan (KTH)

King's College London

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Jan Borén

Sahlgrenska universitetssjukhuset

Oktay Olmuscelik

Istanbul Medipol Universitesi

Levent Doganay

University of Health Sciences

Mathias Uhlen

Kungliga Tekniska Högskolan (KTH)

Adil Mardinoglu

King's College London

Kungliga Tekniska Högskolan (KTH)

Advanced Science

2198-3844 (ISSN)

Vol. In Press

Ämneskategorier

Kirurgi

Gastroenterologi

Kardiologi

DOI

10.1002/advs.202101222

PubMed

34180141

Mer information

Senast uppdaterat

2021-07-08