Fat tissue equivalent phantoms for microwave applications by reinforcing gelatin with nanocellulose
Artikel i vetenskaplig tidskrift, 2021

Tissue mimicking phantom materials with thermal and dielectric equivalence are vital for the development of microwave diagnostics and treatment. The current phantoms representing fat tissue are challenged by mechanical integrity at relevant temperatures coupled with complex production protocols. We have employed two types of nanocellulose (cellulose nanocrystals and oxidized cellulose nanocrystals) as reinforcement in gelatin stabilized emulsions for mimicking fat tissue. The nanocellulose-gelatin stabilized emulsions were evaluated for their dielectric properties, the moduli-temperature dependence using small deformation rheology, stress-strain behavior using large deformation, and their compliance to quality assurance guidelines for superficial hyperthermia. All emulsions had low permittivity and conductivity within the lower microwave frequency band, accompanied by fat equivalent thermal properties. Small deformation rheology showed reduced temperature dependence of the moduli upon addition of nanocellulose, independent of type. The cellulose nanocrystals gelatin reinforced emulsion complied with the quality assurance guidelines. Hence, we demonstrate that the addition of cellulose nanocrystals to gelatin stabilized emulsions has the potential to be used as fat phantoms for the development of microwave diagnostics and treatment.

tissue-mimicking phantom

gel

microwave diagnostics

emulsion

hyperthermia

rheology

Författare

Hana Dobsicek Trefna

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

Saül Llacer Navarro

Wallenberg Wood Science Center (WWSC)

Chalmers, Elektroteknik

Fredrik Lorentzon

Student vid Chalmers

Tiina Nypelö

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Wallenberg Wood Science Center (WWSC)

Anna Ström

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Anna Ström Group

Biomedical Physics and Engineering Express

2057-1976 (eISSN)

Vol. 7 6 065025

Ämneskategorier

Livsmedelsteknik

Polymerteknologi

Textil-, gummi- och polymermaterial

DOI

10.1088/2057-1976/ac2634

PubMed

34517355

Mer information

Senast uppdaterat

2021-11-01