Glycan processing in gut microbiomes
Reviewartikel, 2022

Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the utilization of common and atypical dietary glycans as well as host-derived mucus glycans. In parallel, we discuss findings from multi-omic studies that have provided new perspectives on understanding glycan-dependent interactions and the complex food-webs of microbial populations in their natural habitat. Using key examples, we emphasize how increasing understanding of glycan processing by gut microbiomes can provide critical insights to assist ‘microbiome reprogramming’, a growing field that seeks to leverage diet to improve animal growth and host health.

Författare

Sabina Leanti La Rosa

Norges miljø- og biovitenskapelige universitet

Matthew Ostrowski

University of Michigan

Arturo Vera-Ponce de León

Norges miljø- og biovitenskapelige universitet

Lauren S McKee

Kungliga Tekniska Högskolan (KTH)

Johan Larsbrink

Chalmers, Biologi och bioteknik, Industriell bioteknik

Vincent G.H. Eijsink

Norges miljø- og biovitenskapelige universitet

Elisabeth Lowe

Newcastle University

Eric Martens

University of Michigan

Phillip B. Pope

Norges miljø- og biovitenskapelige universitet

Current Opinion in Microbiology

1369-5274 (ISSN)

Vol. 67 102143

Utveckling av en konsoliderad bioprocess för omvandling av växtbiomassa till mångsidiga kemiska byggstenar

Vetenskapsrådet (VR) (2016-03931), 2017-01-01 -- 2020-12-31.

ÅForsk (17-345), 2017-07-01 -- 2018-05-31.

Novo Nordisk Fonden (NNF17OC0027648), 2018-01-01 -- 2020-12-31.

Drivkrafter

Hållbar utveckling

Fundament

Grundläggande vetenskaper

Styrkeområden

Hälsa och teknik

Livsvetenskaper och teknik (2010-2018)

Ämneskategorier

Mikrobiologi

Mikrobiologi inom det medicinska området

Bioinformatik och systembiologi

DOI

10.1016/j.mib.2022.102143

Mer information

Senast uppdaterat

2022-04-05