Dietary Sources of Anthocyanins and Their Association with Metabolome Biomarkers and Cardiometabolic Risk Factors in an Observational Study
Artikel i vetenskaplig tidskrift, 2023
Anthocyanins (ACNs) are (poly)phenols associated with reduced cardiometabolic risk. Associations between dietary intake, microbial metabolism, and cardiometabolic health benefits of ACNs have not been fully characterized. Our aims were to study the association between ACN intake, considering its dietary sources, and plasma metabolites, and to relate them with cardiometabolic risk factors in an observational study. A total of 1351 samples from 624 participants (55% female, mean age: 45 ± 12 years old) enrolled in the DCH-NG MAX study were studied using a targeted metabolomic analysis. Twenty-four-hour dietary recalls were used to collect dietary data at baseline, six, and twelve months. ACN content of foods was calculated using Phenol Explorer and foods were categorized into food groups. The median intake of total ACNs was 1.6mg/day. Using mixed graphical models, ACNs from different foods showed specific associations with plasma metabolome biomarkers. Combining these results with censored regression analysis, metabolites associated with ACNs intake were: salsolinol sulfate, 4-methylcatechol sulfate, linoleoyl carnitine, 3,4-dihydroxyphenylacetic acid, and one valerolactone. Salsolinol sulfate and 4-methylcatechol sulfate, both related to the intake of ACNs mainly from berries, were inversely associated with visceral adipose tissue. In conclusion, plasma metabolome biomarkers of dietary ACNs depended on the dietary source and some of them, such as salsolinol sulfate and 4-methylcatechol sulfate may link berry intake with cardiometabolic health benefits.
metabolomics
gut microbiota
food matrix
diet
berries
anthocyanins
cardiometabolic health
Författare
Hamza Mostafa
CIBER - Centro de Investigación Biomédica en Red
Universitat de Barcelona
Tomás Meroño
Universitat de Barcelona
CIBER - Centro de Investigación Biomédica en Red
Antonio Miñarro
CIBER - Centro de Investigación Biomédica en Red
Universitat de Barcelona
Alex Sánchez-Pla
Universitat de Barcelona
CIBER - Centro de Investigación Biomédica en Red
Fabian Lanuza
CIBER - Centro de Investigación Biomédica en Red
Universitat de Barcelona
Raul Zamora-Ros
Bellvitge Biomedical Research Institute IDIBELL
Universitat de Barcelona
Agneta Rostgaard-Hansen
Danish Cancer Research Society Center
Núria Estanyol-Torres
Universitat de Barcelona
Marta Cubedo-Culleré
Universitat de Barcelona
Anne Tjønneland
Danish Cancer Research Society Center
Rikard Landberg
Chalmers, Life sciences, Livsmedelsvetenskap
Jytte Halkjær
Danish Cancer Research Society Center
Cristina Andres-Lacueva
CIBER - Centro de Investigación Biomédica en Red
Universitat de Barcelona
Nutrients
2072-6643 (ISSN) 20726643 (eISSN)
Vol. 15 5 1208Nya blodbaserade biomarkörer för spegling av mikrobiota, kost och deras interaktion associerad med typ 2 diabetes risk
Vetenskapsrådet (VR) (2019-01264), 2020-01-01 -- 2022-12-31.
Optimal kost utifrån metabotyp för hälsa och vällevnad
Formas (2016-00314), 2016-01-01 -- 2021-12-31.
Ämneskategorier (SSIF 2011)
Livsmedelsvetenskap
Miljömedicin och yrkesmedicin
Näringslära
DOI
10.3390/nu15051208
PubMed
36904207