Towards personalized drug delivery via semi-solid extrusion: Exploring poly(vinyl alcohol-co-vinyl acetate) copolymers for hydrochlorothiazide-loaded films
Artikel i vetenskaplig tidskrift, 2024

The increasing need for personalized drug delivery requires developing systems with tailorable properties. The copolymer poly(vinyl alcohol-co-vinyl acetate) (PVA/PVAc) allows for adjusting the monomer ratio. This study explored the effect of vinyl alcohol (VA) and vinyl acetate (VAc) monomer ratio on the properties of hydrochlorothiazide (HCT) films. Five copolymers with different VA/VAc ratios were selected and characterized. Semi-solid extrusion was employed as a method for the preparation of HCT-PVA/PVAc films to address the challenges of HCT´s low water solubility, high melting point, and low permeability. All copolymers were suitable for semi-solid extrusion, however, the mechanical properties of films with higher VA proportions were more suitable. The drug was found to be homogeneously distributed on a micrometer level throughout the prepared films. It was found that using different monomer ratios in the copolymer allows for drug release tuning – higher VA proportions showed an increased rate of drug release. Experiments through HT29-MTX cell monolayers revealed differences in HCT permeability between the different formulations. In addition, no cytotoxicity was observed for the tested formulations. The results highlight the effect of monomer ratio on film properties, providing valuable guidance for formulators in selecting PVA/PVAc copolymers for achieving desired high-quality films. In addition, varying the monomer ratio allows tuning of the film properties, and can be applied for personalization, with flexible-dose adjustment and design of appealing shapes of the pharmaceutics, not least attractive for pediatric drug delivery.

HT29-MTX cell line

Biocompatibility

Modified drug release

Permeability

Mechanical properties

Block copolymers

Författare

Karin Korelc

Universitetet i Oslo

Bjarke Strøm Larsen

Universitetet i Oslo

Anna Lena Heintze

Universitetet i Oslo

Julius-Maximilians Universität Würzburg

Åke Henrik-Klemens

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Jakob Karlsson

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Anette Larsson

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Ingunn Tho

Universitetet i Oslo

European Journal of Pharmaceutical Sciences

0928-0987 (ISSN) 1879-0720 (eISSN)

Vol. 192 106645

Design for Circularity: Lignocellulose based Thermoplastics - Fib:Re

VINNOVA (2019-00047), 2020-01-01 -- 2024-12-31.

Ämneskategorier

Polymerkemi

Farmaceutisk vetenskap

DOI

10.1016/j.ejps.2023.106645

PubMed

37984596

Mer information

Senast uppdaterat

2023-12-11