Phase-separated polymer blends for controlled drug delivery by tuning morphology
Artikel i vetenskaplig tidskrift, 2024
Controlling drug release rate and providing physical and chemical stability to the active pharmaceutical ingredient are key properties of oral solid dosage forms. Here, we demonstrate a formulation strategy using phase-separated polymer blends where the morphology provides a route for tuning the drug release profile. By utilising phase separation of a hydrophobic and a hydrophilic polymer, the hydrophilic component will act as a channelling agent, creating a porous network upon dissolution that will dictate the release characteristics. With ptychographic X-ray tomography and scanning transmission X-ray microscopy we reveal how the morphology depends on both polymer fraction and presence of drug, and how the drug is distributed over the polymer domains. Combining X-ray imaging results with dissolution studies reveal how the morphologies are correlated with the drug release and showcase how tuning the morphology of a polymer matrix in oral formulations can be utilised as a method for controlled drug release.
Författare
Martina Olsson
Chalmers, Fysik, Materialfysik
Robin Storm
Chalmers, Kemi och kemiteknik, Tillämpad kemi
Linnea Björn
Chalmers, Fysik, Materialfysik
Viktor Lilja
Chalmers, Fysik, Kondenserad materie- och materialteori
Leonard Krupnik
Université de Fribourg
Eidgenössische Materialprüfungs- und Forschungsanstalt (Empa)
Yang Chen
Paul Scherrer Institut
Polina Naidjonoka
Chalmers, Fysik, Materialfysik
Ana Diaz
Paul Scherrer Institut
M. Holler
Paul Scherrer Institut
Benjamin Watts
Paul Scherrer Institut
Anette Larsson
Chalmers, Kemi och kemiteknik, Tillämpad kemi
Marianne Liebi
Paul Scherrer Institut
Chalmers, Fysik, Materialfysik
Ecole Polytechnique Federale de Lausanne (EPFL)
Aleksandar Matic
Chalmers, Fysik, Materialfysik
Communications Materials
26624443 (eISSN)
Vol. 5 1 231Ämneskategorier
Polymerkemi
Farmaceutisk vetenskap
Materialkemi
DOI
10.1038/s43246-024-00678-y